Fukuyama Zoo, Fukuda-276-1 Ashida-cho, Fukuyama, Hiroshima, Japan,
Fukuyama Zoo, Fukuda-276-1 Ashida-cho, Fukuyama, Hiroshima, Japan.
J Zoo Wildl Med. 2021 Jan;51(4):1062-1066. doi: 10.1638/2019-0152.
In 2015, an estimated 17-year-old female Bornean elephant () at Fukuyama Zoo in Japan exhibited anorexia and significant weight loss. Pan-susceptible complex (MTBC) was isolated from vaginal discharge, oral mucus, urine, and fecal samples by culture. The isolate was identified as by genetic analysis. Isoniazid, pyrazinamide, and levofloxacin were administered rectally. Body weight increased to normal, but subsequently decreased again. Elevation of liver enzymes occurred, likely related to the increase in isoniazid dosage. After recovery from side effects, the elephant's weight increased further. However, isoniazid-resistant was isolated from oral mucus after anti-tuberculosis drug treatment for 9 mo. The regimen was changed to rifampicin, pyrazinamide, ethambutol, and levofloxacin, administered orally or rectally. The 18-mo treatment was completed in October 2018. This elephant has shown no clinical sign since. No MTBC-positive sample had been obtained as of March 2020.
2015 年，日本福冈动物园一只估计年龄为 17 岁的雌性婆罗洲象（）出现食欲不振和明显体重减轻的症状。通过培养从阴道分泌物、口腔粘液、尿液和粪便样本中分离出泛易感复合群（MTBC）。通过基因分析鉴定该分离株为。通过直肠给予异烟肼、吡嗪酰胺和左氧氟沙星。体重增加至正常，但随后再次下降。肝酶升高，可能与异烟肼剂量增加有关。在副作用恢复后，大象的体重进一步增加。然而，在抗结核药物治疗 9 个月后，从口腔粘液中分离出异烟肼耐药。治疗方案更改为利福平、吡嗪酰胺、乙胺丁醇和左氧氟沙星，口服或直肠给药。2018 年 10 月完成了 18 个月的治疗。自那以后，这头大象没有出现任何临床症状。截至 2020 年 3 月，尚未获得 MTBC 阳性样本。
