Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow, 117997, Russia.
Nat Prod Rep. 2021 Aug 1;38(8):1506-1517. doi: 10.1039/d0np00082e. Epub 2021 Jan 22.
This review on atypical angucyclinones possessing an aromatic cleavage of the C-ring covers literature between 1995 and early 2020.The unusual framework of the middle C-ring, "broken" as a result of biotransformations and oxidations in vivo and bearing an sp-C connection, is of interest for biosynthetic investigations. The reported 39 natural compounds (55 including stereoisomers) have been analyzed and arranged into three structural groups. The biosynthetic origin of all these compounds has been thoroughly reviewed and revised, based on the found connections with oxidized angucyclinone structures. The data on biological activities has been summarized. Careful consideration of the origin of the structure allowed us to outline a hypothesis on the biological function as well as prospective applications of such atypical angucyclinones.
这篇关于具有 C 环芳香裂解的非典型蒽环酮的综述涵盖了 1995 年至 2020 年初的文献。C 环中间结构的不寻常框架，由于体内的生物转化和氧化而“断裂”，并带有 sp-C 连接，这对于生物合成研究很有意义。报道的 39 种天然化合物（包括立体异构体在内的 55 种）已经进行了分析，并分为三个结构组。基于与氧化蒽环酮结构的发现联系，对所有这些化合物的生物合成起源进行了彻底的综述和修订。对生物活性数据进行了总结。对结构起源的仔细考虑使我们能够概述这种非典型蒽环酮的生物学功能以及潜在应用的假设。
