Sechi Leonardo A, Colussi Gianluca, Bulfone Luca, Brosolo Gabriele, Da Porto Andrea, Peghin Maddalena, Patruno Vincenzo, Tascini Carlo, Catena Cristiana
Division of Internal Medicine (L.A.S., L.B., A.D.P.), Department of Medicine, University of Udine, 33100, Udine, Italy.
Department of Medicine, Clinica Medica, University of Udine, University Hospital, Building 8, 33100, Udine, Italy.
Clin Res Cardiol. 2021 Jul;110(7):1063-1072. doi: 10.1007/s00392-020-01800-z. Epub 2021 Jan 22.
COVID-19 has caused considerable morbidity and mortality worldwide and cardiac involvement has been reported during infection. The short-term cardiac outcome in survivors of COVID-19 is not known.
To examine the heart of patients who survived COVID-19 and to compare the cardiac outcome between patients who recovered from mild-to-moderate or severe illness.
With use of ECG and echocardiography, we examined the heart of 105 patients who had been hospitalized with COVID-19 and were consecutively recruited after hospital discharge while attending follow-up visits. Survivors of COVID-19 were compared with 105 matched controls. We also compared the cardiac outcome and lung ultrasound scan between COVID-19 patients who had mild-to-moderate or severe illness.
Cardiac data were collected a median of 41 days from the first detection of COVID-19. Symptoms were present in a low percentage of patients. In comparison with matched controls, no considerable structural or functional differences were observed in the heart of survivors of COVID-19. Lung ultrasound scan detected significantly greater residual pulmonary involvement in COVID-19 patients who had recovered from severe than mild-to-moderate illness. No significant differences were detected in ECG tracings nor were found in the left and right ventricular function of patients who had recovered from mild-to-moderate or severe illness.
In a short-term follow-up, no abnormalities were identified in the heart of survivors of COVID-19, nor cardiac differences were detected between patients who had different severity of illness. With the limitations of a cross-sectional study, these findings suggest that patients who recover from COVID-19 do not have considerable cardiac sequelae.
新型冠状病毒肺炎（COVID-19）已在全球范围内造成了相当高的发病率和死亡率，并且在感染期间已有心脏受累的报道。COVID-19幸存者的短期心脏结局尚不清楚。
检查COVID-19幸存者的心脏，并比较从轻度至中度或重度疾病中康复的患者之间的心脏结局。
我们使用心电图和超声心动图检查了105例因COVID-19住院且出院后连续招募进行随访的患者的心脏。将COVID-19幸存者与105名匹配的对照进行比较。我们还比较了患有轻度至中度或重度疾病的COVID-19患者之间的心脏结局和肺部超声扫描结果。
从首次检测到COVID-19起，中位41天收集了心脏数据。出现症状的患者比例较低。与匹配的对照相比，未观察到COVID-19幸存者的心脏存在明显的结构或功能差异。肺部超声扫描显示，从重度疾病中康复的COVID-19患者的肺部残留受累明显大于从轻度至中度疾病中康复的患者。在轻度至中度或重度疾病康复患者的心电图描记中未检测到显著差异，左、右心室功能也未发现显著差异。
在短期随访中，未在COVID-19幸存者的心脏中发现异常，不同疾病严重程度的患者之间也未检测到心脏差异。鉴于横断面研究的局限性，这些发现表明从COVID-19中康复的患者没有明显的心脏后遗症。
