Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
Department of Anatomy, All India Institute of Medical Sciences-Patna, (AIIMS-P), Patna, India.
Viral Immunol. 2021 Jun;34(5):352-357. doi: 10.1089/vim.2020.0277. Epub 2021 Jan 21.
Intense immunological dysregulation including immune cell lesions has been characteristically observed in severe cases of coronavirus disease-2019 (COVID-19), for which molecular mechanisms are not properly understood. A study of physiological expressions of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) host cell entry-related factors in immune system components may help explain molecular mechanisms involved in COVID-19 immunopathology. We analyzed transcriptomic and proteomic expression metadata for SARS-CoV-2 host cell entry receptor and entry associated proteases (, , and ) across immune system components including the blood lineage cells. was not detected in any of the studied immune cell components; however, varying transcriptomic and proteomic expressions were observed for , , and . Nondetectable expressions of SARS-CoV-2 host cell entry receptor in immune system components or blood lineage cells indicate it does not mediate immune cell lesions in COVID-19. Alternative mechanisms need to be explored for COVID-19 immunopathogenesis.
在 2019 冠状病毒病（COVID-19）的重症病例中，观察到强烈的免疫失调，包括免疫细胞损伤，但其分子机制尚不清楚。研究严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）宿主细胞进入相关因素在免疫系统成分中的生理表达，可能有助于解释 COVID-19 免疫病理学涉及的分子机制。我们分析了 SARS-CoV-2 宿主细胞进入受体和进入相关蛋白酶（、、和）在包括血液谱系细胞在内的免疫系统成分中的转录组和蛋白质组表达元数据。在研究的任何免疫细胞成分中均未检测到 ；然而， 和 表现出不同的转录组和蛋白质组表达。SARS-CoV-2 宿主细胞进入受体在免疫系统成分或血液谱系细胞中不可检测的表达表明，它不会介导 COVID-19 中的免疫细胞损伤。需要探索 COVID-19 免疫发病机制的替代机制。
