Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Research Division, National Research Centre, El Buhouth St., Dokki, 12311 Giza, Egypt.
Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Research Division, National Research Centre, El Buhouth St., Dokki, 12311 Giza, Egypt.
Int J Biol Macromol. 2021 Mar 15;173:79-89. doi: 10.1016/j.ijbiomac.2021.01.110. Epub 2021 Jan 19.
Exopolysaccharides (EPS) are important bioproducts produced by some genera of lactic acid bacteria. EPS are famous for their shelf-life improving properties, techno-functional enhancing abilities in food and dairy industries, besides their beneficial health effects. Furthermore, exopolysaccharides have many prospective and well-established contributions in the field of drugs and diagnostic industry. In this review, classification of EPS produced by LAB was presented. Moreover, current and potential applications of EPS in food, dairy, baking industries, cereal-based, and functional products were described. Also, some clinical and pharmaceutical applications of EPS such as intelligent drug delivery systems (microsystems and nanosystems for sustained delivery), interpenetrating polymer networks (IPNs), anticancer drug-targeting, recombinant macromolecular biopharmaceuticals, gene delivery, tissue engineering, and role of EPS in diagnostics were highlighted. Finally, future prospects concerning enhancing EPS production, minimizing costs of their production, and exploring their contribution in further applications were discussed.
胞外多糖（EPS）是一些乳酸菌属产生的重要生物产物。EPS 以其延长保质期的特性、在食品和乳制品行业中增强技术和功能的能力而闻名，此外，它们还有益于健康。此外，胞外多糖在药物和诊断行业领域有许多有前景和成熟的贡献。在这篇综述中，介绍了 LAB 产生的 EPS 的分类。此外，还描述了 EPS 在食品、乳制品、烘焙、谷物和功能性产品中的当前和潜在应用。还强调了 EPS 在临床和药物方面的一些应用，如智能药物输送系统（用于持续输送的微系统和纳米系统）、互穿聚合物网络（IPN）、抗癌药物靶向、重组大分子生物制药、基因传递、组织工程以及 EPS 在诊断中的作用。最后，讨论了关于提高 EPS 产量、降低其生产成本以及探索其在进一步应用中的贡献的未来前景。
