University of Illinois at Chicago, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, 60612, United States.
University of Illinois at Chicago, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, 60612, United States.
Free Radic Biol Med. 2021 Jul;170:34-43. doi: 10.1016/j.freeradbiomed.2021.01.010. Epub 2021 Jan 19.
Nitric oxide (NO) and hydrogen sulfide (HS) were previously only known for their toxic properties. Now they are regarded as potent gaseous messenger molecules (gasotransmitters) that rapidly transverse cell membranes and transduce cellular signals through their chemical reactions and modifications to protein targets. Both are known to regulate numerous physiological functions including angiogenesis, vascular tone, and immune response, to name a few. NO and HS often work synergistically and in competition to regulate each other's synthesis, target protein activity via posttranslational modifications (PTMs), and chemical interactions. In addition to their canonical modes of action, increasing evidence has demonstrated that NO and HS share another signaling mechanism: epigenetic regulation. This review will compare and contrast biosynthesis and metabolism of NO and HS, their individual and shared interactions, and the growing body of evidence for their roles as endogenous epigenetic regulatory molecules.
一氧化氮 (NO) 和硫化氢 (HS) 以前仅因其毒性而为人所知。现在，它们被认为是有效的气态信使分子（气体递质），能够通过化学反应和对蛋白质靶标的修饰快速穿过细胞膜并传递细胞信号。这两种物质都已知能够调节多种生理功能，包括血管生成、血管张力和免疫反应等。NO 和 HS 通常协同作用并相互竞争以调节彼此的合成、通过翻译后修饰 (PTM) 调节靶蛋白活性以及化学相互作用。除了它们的典型作用模式外，越来越多的证据表明，NO 和 HS 还具有另一种信号机制：表观遗传调控。本文将比较和对比 NO 和 HS 的生物合成和代谢、它们的单独和共同相互作用，以及它们作为内源性表观遗传调节分子的作用的不断增加的证据。
