整合素连接激酶（ILK）及其在肝脏病理生物学中的作用。
Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology.
机构信息
Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA.
出版信息
Gene Expr. 2021 Jun 11;20(3):201-207. doi: 10.3727/105221621X16113475275710. Epub 2021 Jan 22.
Abstract
Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma.
摘要
整合素连接激酶（ILK）是一种普遍表达于全身的重要信号蛋白。它与细胞内整合素结合，有助于促进与细胞黏附、细胞凋亡、增殖、迁移和其他许多常见细胞功能相关的信号转导。在这篇综述中，详细介绍了 ILK 在肝脏中的作用。研究表明，ILK 是肝细胞外基质组织、肝再生、胰岛素抵抗和肝细胞癌的主要参与者。
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