Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
J Clin Endocrinol Metab. 2021 Apr 23;106(5):e2228-e2238. doi: 10.1210/clinem/dgab037.
Adipose tissue dysfunction is characterized by decreased adiponectin (AN) levels and impaired adipose tissue insulin sensitivity (ATIS) and is associated with metabolic disorders. While Asians readily develop metabolic disease without obesity, it remains unclear how decreased AN level and impaired ATIS affect metabolic abnormalities in nonobese Asians.
To investigate the relationships between decreased AN level, impaired ATIS, and metabolic abnormalities, we studied 94 Japanese men whose body mass index was less than 25 kg/m2. We divided the subjects into 4 groups based on their median AN level and ATIS, the latter calculated as the degree of insulin-mediated suppression of free fatty acids during hyperinsulinemic euglycemic clamp, and compared the metabolic parameters in the 4 groups.
The High-ATIS/High-AN group (n = 29) showed similar anthropometric data to the High-ATIS/Low-AN group (n = 18). In contrast, both the Low-ATIS/High-AN (n = 18) and Low-ATIS/Low-AN (n = 29) groups showed significantly lower muscle insulin sensitivity than the High-ATIS groups. The intrahepatic lipid level in the Low-ATIS/Low-AN group was significantly higher than that in the High-ATIS groups. In addition, the Low-ATIS/Low-AN group had a significantly higher fasting serum triglyceride level and significantly lower high-density lipoprotein cholesterol level than the other 3 groups.
In nonobese Japanese men with high ATIS, the AN level was not associated with metabolic characteristics. On the other hand, subjects with low ATIS showed reduced muscle insulin sensitivity, and those with a decreased AN level demonstrated multiple metabolic abnormalities, represented by fatty liver and dyslipidemia.
脂肪组织功能障碍的特征是脂联素（AN）水平降低和脂肪组织胰岛素敏感性（ATIS）受损，与代谢紊乱有关。虽然亚洲人在没有肥胖的情况下很容易患上代谢疾病，但目前尚不清楚 AN 水平降低和 ATIS 受损如何影响非肥胖亚洲人的代谢异常。
为了研究 AN 水平降低、ATIS 受损与代谢异常之间的关系，我们研究了 94 名日本男性，他们的体重指数（BMI）小于 25kg/m2。我们根据他们的中位数 AN 水平和 ATIS 将受试者分为 4 组，后者计算为在高胰岛素正常血糖钳夹期间胰岛素介导的游离脂肪酸抑制程度，并比较了 4 组的代谢参数。
高 ATIS/高 AN 组（n=29）的人体测量数据与高 ATIS/低 AN 组（n=18）相似。相比之下，低 ATIS/高 AN 组（n=18）和低 ATIS/低 AN 组（n=29）的肌肉胰岛素敏感性均明显低于高 ATIS 组。低 ATIS/低 AN 组的肝内脂肪水平明显高于高 ATIS 组。此外，低 ATIS/低 AN 组的空腹血清甘油三酯水平明显高于其他 3 组，高密度脂蛋白胆固醇水平明显低于其他 3 组。
在 ATIS 较高的非肥胖日本男性中，AN 水平与代谢特征无关。另一方面，ATIS 较低的受试者表现出肌肉胰岛素敏感性降低，而 AN 水平降低的受试者则表现出多种代谢异常，表现为脂肪肝和血脂异常。
