Wu Mingxia, Hu Chunyu, Yu He, Sun Li, Chen Zongtao
Health Management Center, First Affiliated Hospital of Army Medical University (Third Military Medical University), Chongqing, 400038, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Aug 20;18:2945-2954. doi: 10.2147/DMSO.S522521. eCollection 2025.
Numerous studies have investigated adiponectin in disease populations, but no study has focused on the plasma adiponectin level, adiponectin deficiency, and its influencing factors in the population who have not yet developed disease symptoms.
The data of physical examination subjects who completed adiponectin detection in our hospital from 2020 to 2024 were included. The adiponectin levels in different age, genders, and subgroups were analyzed, and the indicators under adiponectin deficiency (<4 µg/mL in men and <5 µg/mL in women) were compared. The factors that might affect adiponectin deficiency were further included in multivariate logistic regression analysis. The odds ratio (OR) and 95% confidence interval (CI) were calculated to understand the possible risk factors for adiponectin deficiency.
A total of 11829 subjects were included in the study, and the overall rate of adiponectin deficiency was 12.06%. The adiponectin level was generally higher in women; however, there were no significant differences among the subgroups of hypoproteinemia, low HDL-C, and anemia. Besides, hyperglycemia (OR: 2.02, 95% CI: 1.64-2.50), obesity (OR: 2.34, 95% CI: 1.87-2.91), hypertriglyceridemia (OR: 2.17, 95% CI: 1.89-2.48), low HDL-C (OR: 2.09, 95% CI: 1.66-2.65), increased PLT count (OR: 2.57, 95% CI: 1.57-4.50) and elevated ALT (OR: 1.48, 95% CI: 1.24-1.76) are associated with higher adiponectin deficiency. However, no significant associations were observed between adiponectin deficiency and gender, blood pressure, or elevated LDL-C.
The adiponectin level is generally higher in women than in men except for subjects with anemia, hypoproteinemia, and low HDL-C. Overweight/obesity, hypertriglyceridemia, low HDL-C, hyperuricemia, hyperglycemia, elevated ALT, and increased PLT count may be the risk factors for adiponectin deficiency. When these risk factors are present, targeted adiponectin testing is recommended.
众多研究已对疾病人群中的脂联素进行了调查，但尚无研究聚焦于尚未出现疾病症状人群的血浆脂联素水平、脂联素缺乏情况及其影响因素。
纳入2020年至2024年在我院完成脂联素检测的体检受试者数据。分析不同年龄、性别及亚组中的脂联素水平，并比较脂联素缺乏（男性<4μg/mL，女性<5μg/mL）情况下的各项指标。将可能影响脂联素缺乏的因素进一步纳入多因素logistic回归分析。计算比值比（OR）及95%置信区间（CI），以了解脂联素缺乏的可能危险因素。
本研究共纳入11829名受试者，脂联素缺乏的总体发生率为12.06%。女性的脂联素水平总体较高；然而，在低蛋白血症、低高密度脂蛋白胆固醇（HDL-C）及贫血亚组之间无显著差异。此外，高血糖（OR：2.02，95%CI：1.64 - 2.50）、肥胖（OR：2.34，95%CI：1.87 - 2.91）、高甘油三酯血症（OR：2.17，95%CI：1.89 - 2.48）、低HDL-C（OR：2.09，95%CI：1.66 - 2.65）、血小板计数增加（OR：2.57，95%CI：1.57 - 4.50）及丙氨酸转氨酶（ALT）升高（OR：1.48，95%CI：1.24 - 1.76）与脂联素缺乏较高相关。然而，未观察到脂联素缺乏与性别、血压或低密度脂蛋白胆固醇（LDL-C）升高之间存在显著关联。
除贫血、低蛋白血症及低HDL-C受试者外，女性的脂联素水平总体高于男性。超重/肥胖、高甘油三酯血症、低HDL-C、高尿酸血症、高血糖、ALT升高及血小板计数增加可能是脂联素缺乏的危险因素。当存在这些危险因素时，建议进行针对性的脂联素检测。
