School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Chem Soc Rev. 2020 Dec 7;49(23):8774-8789. doi: 10.1039/d0cs01121e. Epub 2020 Oct 22.
Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.
金纳米粒子（AuNPs）因其独特的性质及其生物相容性、低毒性、多价性和尺寸可调性而受到越来越多的关注，使它们成为令人兴奋的药物载体。通过将靶向部分功能化 AuNPs，可以将其选择性递送到癌症部位，利用抗体、蛋白质、肽、适体、碳水化合物和小分子等。在这里，我们综述了用于治疗癌症的靶向 AuNPs 的最新进展，特别关注这些靶向配体类别。我们强调了每个配体类别的优点和潜在缺点，并提出了该领域可能的发展方向。
