Su Xin, Zhang Guoming, Cheng Ye, Wang Bin
Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.
Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.
Clin Chim Acta. 2021 May;516:8-14. doi: 10.1016/j.cca.2021.01.013. Epub 2021 Jan 21.
In obesity, adipocytes are dysfunctional with excessive production and secretion of pro-inflammatory hormones and cytokines, ie, adipokines, such as tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) and leptin. Accumulating evidence has shown that leptin possesses pleiotropic functions including stimulation of angiogenesis and production of pro-inflammatory cytokines. Furthermore, various leptin associated activities involve a wide distribution of leptin receptors. For example, increased serum leptin was associated with tissue receptor resistance in metabolic syndrome. Although increased serum leptin, receptor and signaling impairment are involved in wound healing, hair cycle and the pathogenesis of many skin diseases such as psoriasis and lupus erythematosus as well as skin cancer, its exact role remains unclear. In the present article, we discuss the biochemistry of leptin action and its potential role in the pathophysiology of diverse skin diseases.
在肥胖症中，脂肪细胞功能失调，会过度产生和分泌促炎激素及细胞因子，即脂肪因子，如肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）和瘦素。越来越多的证据表明，瘦素具有多种功能，包括刺激血管生成和促炎细胞因子的产生。此外，各种与瘦素相关的活动涉及瘦素受体的广泛分布。例如，代谢综合征患者血清瘦素水平升高与组织受体抵抗有关。尽管血清瘦素水平升高、受体及信号传导受损与伤口愈合、毛发周期以及许多皮肤病如银屑病、红斑狼疮和皮肤癌的发病机制有关，但其确切作用仍不清楚。在本文中，我们将讨论瘦素作用的生物化学及其在多种皮肤病病理生理学中的潜在作用。
