Department of Dermatology, Centre of Postgraduate Medical Education, Woloska 137, 02-507, Warsaw, Poland.
Department of Endocrinology, Centre of Postgraduate Medical Education, Ceglowska 80, 01-809, Warsaw, Poland.
Lipids Health Dis. 2020 Oct 2;19(1):215. doi: 10.1186/s12944-020-01391-8.
Leptin is an adipokine, adipocyte-derived compound, which acts both as a hormone and cytokine. It is mainly synthesized by adipocytes of white adipose tissue. Leptin possesses pleiotropic functions including, among others, stimulation of angiogenesis and production of proinflammatory cytokines. The various types of leptin activity are related to the wide distribution of leptin receptors. This adipokine acts by activating intracellular signaling cascades such as JAKs (Janus kinases), STATs (signal transducers and activators of transcription), and others.In a course of obesity, an increased serum level of leptin coexists with tissue receptor resistance. It has been reported that enhanced leptin levels, leptin receptor impairment, and dysfunction of leptin signaling can influence skin and hair. The previous studies revealed the role of leptin in wound healing, hair cycle, and pathogenesis of skin diseases like psoriasis, lupus erythematosus, and skin cancers. However, the exact mechanism of leptin's impact on the skin is still under investigation. Herein, we present the current knowledge concerning the role of leptin in psoriasis and selected skin diseases.
瘦素是一种脂肪细胞因子，由白色脂肪组织中的脂肪细胞合成。它主要作为一种激素和细胞因子发挥作用。瘦素有多种功能，包括刺激血管生成和产生促炎细胞因子。各种类型的瘦素活性与瘦素受体的广泛分布有关。这种脂肪细胞因子通过激活细胞内信号级联反应（如 JAKs（Janus 激酶）、STATs（信号转导和转录激活因子）等）发挥作用。在肥胖过程中，血清瘦素水平升高与组织受体抵抗并存。据报道，增强的瘦素水平、瘦素受体损伤以及瘦素信号转导功能障碍会影响皮肤和毛发。先前的研究表明，瘦素在伤口愈合、毛发周期以及银屑病、红斑狼疮和皮肤癌等皮肤病的发病机制中发挥作用。然而，瘦素对皮肤的影响的确切机制仍在研究中。本文介绍了目前关于瘦素在银屑病和某些皮肤疾病中的作用的知识。
