Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, the Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, 410011, Hunan, China.
Department of Cardiovascular Medicine, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Lipids Health Dis. 2019 Sep 14;18(1):171. doi: 10.1186/s12944-019-1115-3.
Psoriasis is a chronic, systemic, hyper-proliferative immune-mediated inflammatory skin disease. The results of epidemiological investigations have shown that psoriasis affects around 2% of the general population worldwide, and the total number of psoriasis patients is more than 6 million in China. Apart from the skin manifestations, psoriasis has been verified to associate with several metabolic comorbidities, such as insulin resistance, diabetes and obesity. However, the underlying mechanism is still not elucidated. Adipocytes, considered as the active endocrine cells, are dysfunctional in obesity which displays increased synthesis and secretion of adipokines with other modified metabolic properties. Currently, growing evidence has pointed to the central role of adipokines in adipose tissue and the immune system, providing new insights into the effect of adipokines in linking the pathophysiology of obesity and psoriasis. In this review, we summarize the current understanding of the pathological role of adipokines and the potential mechanisms whereby different adipokines link obesity and psoriasis. Furthermore, we also provide evidence which identifies a potential therapeutic target aiming at adipokines for the management of these two diseases.
银屑病是一种慢性、全身性、过度增殖性的免疫介导性炎症性皮肤病。流行病学调查结果表明，银屑病在全球范围内影响着大约 2%的普通人群，而中国的银屑病患者总数超过 600 万。除了皮肤表现外，银屑病还被证实与多种代谢合并症有关，如胰岛素抵抗、糖尿病和肥胖症。然而，其潜在的发病机制尚不清楚。脂肪细胞被认为是活跃的内分泌细胞，在肥胖症中功能失调，表现为脂肪细胞因子的合成和分泌增加，同时具有其他改变的代谢特性。目前，越来越多的证据表明脂肪细胞因子在脂肪组织和免疫系统中的核心作用，为脂肪细胞因子在连接肥胖症和银屑病的病理生理学方面提供了新的见解。在这篇综述中，我们总结了脂肪细胞因子在银屑病发病机制中的病理作用及其潜在机制，以及不同的脂肪细胞因子如何将肥胖症和银屑病联系起来。此外，我们还提供了一些证据，确定了针对脂肪细胞因子的潜在治疗靶点，以用于这两种疾病的治疗。
