Price R W, Sidtis J, Rosenblum M
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Ann Neurol. 1988;23 Suppl:S27-33. doi: 10.1002/ana.410230711.
The acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) commonly complicates the course of human immunodeficiency virus (HIV) infection and AIDS. Although many of its clinical aspects have recently been brought into clearer focus, and pathogenetic evidence has accrued implicating direct HIV brain infection, there remain a number of fundamental aspects of ADC and HIV nervous system infection that require clarification. These include clearer definition of the clinical syndrome and its variants; development of instrumentation for diagnosis and monitoring the disorder; definition of the epidemiology and natural history of both central nervous system HIV infection and ADC, which may seemingly be discordant; and understanding of both the viral pathogenesis and the biology of resultant brain dysfunction. Elucidation of these fundamental issues will enhance rational development and evaluation of therapy.
获得性免疫缺陷综合征（AIDS）痴呆综合征（ADC）常使人类免疫缺陷病毒（HIV）感染及AIDS的病程复杂化。尽管其许多临床方面最近已更加明确，但已有致病证据表明存在HIV直接感染脑部的情况，然而ADC及HIV神经系统感染仍有许多基本方面需要阐明。这些方面包括更明确地界定临床综合征及其变体；开发用于诊断和监测该疾病的检测手段；明确中枢神经系统HIV感染及ADC的流行病学和自然史，二者看似可能不一致；以及了解病毒发病机制和由此导致的脑功能障碍生物学机制。阐明这些基本问题将有助于合理开发和评估治疗方法。
