Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, (Mohali), Punjab, India.
Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, (Mohali), Punjab, India.
Int J Pharm. 2021 Mar 1;596:120272. doi: 10.1016/j.ijpharm.2021.120272. Epub 2021 Jan 22.
Lipoproteins are endogenously present nanocarriers and are the primary commuters of cholesterol within the body. Among lipoproteins, HDL inherits size in nm range with anti-oxidant potential and receptor affinity which makes them an attractive candidate for drug delivery. Hence, in this review, we glance across the biosynthesis, architecture, and methods to prepare rHDL which acts as an endogenously present delivery vehicle. The review critically describes the range of applications possible for targeted delivery in multiple ailments (cancer, atherosclerosis, Alzheimer, age-related macular degeneration and psoriasis) using rHDL. Moreover, the review also expounds on to the case reports where, drug delivery aspect of rHDL is augmented through stimuli sensitivity (ultrasounds, magnetic field, photodynamic therapy) and pH dependent approaches. Further, the role of rHDL in combating the blood brain barrier for efficient delivery of peptides into the brain is also been highlighted. Additionally, the manuscript also expounds on rHDL based formulations which are under clinical review with elaboration on challenges and future prospects pertaining to their clinical translation. Overall, the present article showcases several aspects of rHDL, which are or can be explored for present and future investigations.
脂蛋白是内源性存在的纳米载体，是体内胆固醇的主要运输者。在脂蛋白中，HDL 具有纳米级的尺寸、抗氧化潜力和受体亲和力，使其成为药物递送的有吸引力的候选物。因此，在这篇综述中，我们回顾了 rHDL 的生物合成、结构和制备方法，rHDL 作为内源性递药载体。该综述批判性地描述了 rHDL 在多种疾病（癌症、动脉粥样硬化、阿尔茨海默病、年龄相关性黄斑变性和银屑病）中的靶向递药的各种应用。此外，该综述还阐述了通过刺激敏感性（超声、磁场、光动力疗法）和 pH 依赖性方法增强 rHDL 的药物递药特性的案例报告。此外，rHDL 在克服血脑屏障以有效将肽递送到大脑中的作用也得到了强调。此外，本文还阐述了正在临床审查中的基于 rHDL 的制剂，详细介绍了与临床转化相关的挑战和未来前景。总的来说，本文展示了 rHDL 的几个方面，这些方面或可用于当前和未来的研究。
