Department of Industrial Engineering of the University of Salerno, via Giovanni Paolo II, 132, Fisciano, SA, Italy.
Department of Industrial Engineering of the University of Salerno, via Giovanni Paolo II, 132, Fisciano, SA, Italy.
J Mech Behav Biomed Mater. 2021 Apr;116:104341. doi: 10.1016/j.jmbbm.2021.104341. Epub 2021 Jan 19.
Alginate based gels are widely adopted in many pharmaceutical and biomedical fields. The main rheological characteristics of the alginate-based gels are important design parameters for gel preparation. A new methodology for rheological tests on the alginate-based gels has been assessed in order to obtain reliable and reproducible results in terms of loss and storage moduli. The methodology accounts for the effect of morphology on the rheological properties. Reliable results can be achieved if the structure of the gel is preserved during the analysis, thus, the control of the load applied during the rheological test plays a crucial role. The application of the proposed methodology allows to obtain information about the cross-linking degree of hydrogels. To this purpose, hydrogels with different ratios of divalent cations and alginate have been adopted. The number of junctions in the network formed during the cross-linking process has been evaluated and the results are consistent with the infrared analysis conducted on the same hydrogels.
基于海藻酸盐的凝胶在许多药物和生物医学领域得到了广泛应用。海藻酸盐基凝胶的主要流变特性是凝胶制备的重要设计参数。为了获得损耗和储能模量方面可靠且可重复的结果，评估了一种新的海藻酸盐基凝胶流变学测试方法。该方法考虑了形态对流变性能的影响。如果在分析过程中保持凝胶的结构，就可以获得可靠的结果，因此，在流变学测试过程中控制施加的负载起着至关重要的作用。该方法的应用可以提供有关水凝胶交联度的信息。为此，采用了不同比例的二价阳离子和海藻酸盐的水凝胶。评估了在交联过程中形成的网络中的交联点数量，结果与对相同水凝胶进行的红外分析一致。
