CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
Comput Biol Med. 2021 Mar;130:104219. doi: 10.1016/j.compbiomed.2021.104219. Epub 2021 Jan 16.
Comorbidities in COVID-19 patients often lead to more severe outcomes. The disease-specific molecular events, which may induce susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, are being investigated. To assess this, we retrieved array-based gene expression datasets from patients of 30 frequently occurring acute, chronic, or infectious diseases. Comparative analyses of the datasets were performed after quantile normalization and log2 transformation. Among the 78 host genes prominently implicated in COVID-19 infection, ACE2 (receptor for SARS-CoV-2) was positively regulated in several cases, namely, leukemia, psoriasis, lung cancer, non-alcoholic fatty liver disease (NAFLD), breast cancer, and pulmonary arterial hypertension (PAH). FURIN was positively regulated in some cases, such as leukemia, psoriasis, NAFLD, lung cancer, and type II diabetes (T2D), while TMPRSS2 was positively regulated in only 3 cases, namely, leukemia, lung cancer, and T2D. Genes encoding various interferons, cytokines, chemokines, and mediators of JAK-STAT pathway were positively regulated in leukemia, NAFLD, and T2D cases. Among the 161 genes that are positively regulated in the lungs of COVID-19 patients, 99-111 genes in leukemia (including various studied subtypes), 77 genes in NAFLD, and 48 genes in psoriasis were also positively regulated. Because of the high similarity in gene expression patterns, the patients of leukemia, NAFLD, T2D, psoriasis, and PAH may need additional preventive care against acquiring SARS-CoV-2 infections. Further, two genes CARBONIC ANHYDRASE 11 (CA11) and CLUSTERIN (CLU) were positively regulated in the lungs of patients infected with either SARS-CoV-2, or SARS-CoV or Middle East Respiratory Syndrome Coronavirus (MERS-CoV).
COVID-19 患者的合并症常常导致更严重的后果。正在研究可能导致严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染易感性的疾病特异性分子事件。为了评估这一点，我们从 30 种常见的急性、慢性或传染性疾病患者中检索了基于阵列的基因表达数据集。对数据集进行了分位数归一化和 log2 转换后的比较分析。在 78 个与 COVID-19 感染密切相关的宿主基因中，ACE2（SARS-CoV-2 的受体）在几种情况下被正向调控，如白血病、银屑病、肺癌、非酒精性脂肪性肝病 (NAFLD)、乳腺癌和肺动脉高压 (PAH)。FURIN 在一些情况下被正向调控，如白血病、银屑病、NAFLD、肺癌和 2 型糖尿病 (T2D)，而 TMPRSS2 仅在 3 种情况下被正向调控，即白血病、肺癌和 T2D。编码各种干扰素、细胞因子、趋化因子和 JAK-STAT 通路介质的基因在白血病、NAFLD 和 T2D 病例中被正向调控。在 COVID-19 患者肺部被正向调控的 161 个基因中，白血病中有 99-111 个基因（包括各种研究亚型）、NAFLD 中有 77 个基因和银屑病中有 48 个基因也被正向调控。由于基因表达模式高度相似，白血病、NAFLD、T2D、银屑病和 PAH 的患者可能需要额外的预防措施来防止感染 SARS-CoV-2。此外，在感染 SARS-CoV-2、SARS 或中东呼吸综合征冠状病毒 (MERS-CoV) 的患者肺部中，两种基因碳酸酐酶 11 (CA11) 和聚类蛋白 (CLU) 被正向调控。
