Skin Center Avezzano, L'Aquila, Italy.
Dermatologic Clinic, Maggiore Hospital of Trieste, Trieste, Italy.
Dermatol Ther. 2021 Mar;34(2):e14799. doi: 10.1111/dth.14799. Epub 2021 Feb 7.
Androgenetic alopecia (AGA) with its precursor miniaturization of anagen phase (MA) and telogen effluvium (TE) represent nonscarring hair loss diseases which causes moderate to severe aesthetic and psychologic discomfort in affected people. Several therapeutic approaches have been tested through the latest decades, with different degree of success. In this study we aim to analyze the efficacy and outcome of an innovative therapeutic protocol, named TRICHOBIOLIGHT, a combination of active principles conveyed by mesotherapy directly on the scalp with a subsequent photobiostimulation session with LED light (630 nm). About 107 patients (49 women, 58 men, mean age 45-year-old) with clinical and trichoscopic diagnosis of MA, AGA, and TE have been enrolled at Skin Center of L'Aquila, Avezzano and Pescara (Italy) and subsequently treated with the TRICHOBIOLIGHT protocol. 4 patients dropped out at the beginning of the study: 2 patients because of an histological diagnosis of scarring alopecia and lichen scleroatrophicus, and 2 patients dropped out because of adverse reaction to the treatment. Excellent to good outcome have been reached in the 82.5% of patients (85/103), 9 patients (8.7%) reached a sufficient result while 7 patients (6.8%) partially respond to the treatment. Two patients (2%) did not respond at all. TRICHOBIOLIGHT is a promising protocol, working through the combined action of the active principles and the photobiostimulation, that lead to a strengthening and thickening of the residual hair, giving an optical thickening effect that provides high quality aesthetic results and, consequently, appreciable psychological results.
雄激素性脱发(AGA)及其前驱期的毛发生长周期(MA)和休止期脱发(TE)表现为非瘢痕性脱发疾病,会导致受影响人群出现中度至重度的美学和心理不适。在过去几十年中,已经测试了几种治疗方法,取得了不同程度的成功。在这项研究中,我们旨在分析一种创新治疗方案的疗效和结果,该方案名为 TRICHOBIOLIGHT,它将中胚层疗法直接作用于头皮的活性成分与随后的 LED 光(630nm)光生物刺激相结合。大约 107 名患者(49 名女性,58 名男性,平均年龄 45 岁),临床和 trichoscopic 诊断为 MA、AGA 和 TE,在拉奎拉、阿韦扎诺和佩斯卡拉(意大利)的皮肤中心接受了 TRICHOBIOLIGHT 方案的治疗。在研究开始时,有 4 名患者退出:2 名患者因组织学诊断为瘢痕性脱发和硬化性苔藓而退出,2 名患者因对治疗的不良反应而退出。82.5%的患者(85/103)达到了极好或良好的疗效,9 名患者(8.7%)达到了足够的疗效,7 名患者(6.8%)对治疗部分有反应。2 名患者(2%)完全没有反应。TRICHOBIOLIGHT 是一种有前途的方案,通过活性成分和光生物刺激的联合作用发挥作用,导致残留毛发的增强和变厚,产生光学增粗效果,提供高质量的美学效果,从而带来明显的心理效果。