Nam Soomin, Kim Dongwook, Jung Kyuwon, Choi Yoon Jung, Kang Jung Gu
Department of Surgery, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Big Data Department, National Health Insurance Service, Wonju, Korea.
Ann Coloproctol. 2020 Dec;36(6):390-397. doi: 10.3393/ac.2020.05.03.2. Epub 2020 May 15.
Although most colorectal malignancies are adenocarcinomas from mucosa, various types of malignant and benign tumors can develop. Due to extremely low incidence, little research has been conducted. The purpose was to assess incidence and compare it according to demographic factors.
Data from the Korea National Cancer Registry from 2007 to 2016 were used. The crude incidence, age-standard incidence rate (ASR) of colorectal nonadenocarcinomas were calculated.
Over 11 years, there were 267,142 patients with colorectal malignancies. The patients of 14,495 (5.43%) were diagnosed with nonadenocarcinoma. The ASR was 2.52 per 100,000 in men and 1.56 in women. Lesions were classified according to histologic categories; neuroendocrine tumor (NET) was the most common malignancy (10,919 [75.33%]). Nonadenocarcinoma was the most common in 40s and 50s (40 to 49 years, 3,530 [24.35%]; 50 to 59 years, 3,991 [27.53%]). Lymphoma was high (54.46%) in patients in teenagers. Proportion of NET decreased with age and that of carcinoma increased with age. Carcinoma, sarcoma, and lymphoma were more common among men and melanoma was more common among women. The most common site was the rectum (11,066 [76.34%]). Lymphoma occurred more frequently in proximal colon. Melanoma, gastrointestinal stromal tumor, and NET occurred mostly in rectum. A total of 10,155 patients (70.06%) were classified as having localized disease.
This study is meaningful as it is the first study to examine incidence of colorectal nonadenocarcinoma. Differences in incidence of different lesions based on demographic factors were identified. This study will play a role in cancer prevention and diagnosis projects.
尽管大多数结直肠恶性肿瘤是源自黏膜的腺癌，但也可发生各种类型的恶性和良性肿瘤。由于发病率极低，相关研究较少。本研究旨在评估其发病率，并根据人口统计学因素进行比较。
使用了韩国国家癌症登记处2007年至2016年的数据。计算了结直肠非腺癌的粗发病率、年龄标准化发病率（ASR）。
在11年期间，共有267,142例结直肠恶性肿瘤患者。其中14,495例（5.43%）被诊断为非腺癌。男性的ASR为每10万人2.52例，女性为1.56例。病变根据组织学类别进行分类；神经内分泌肿瘤（NET）是最常见的恶性肿瘤（10,919例[75.33%]）。非腺癌在40多岁和50多岁人群中最为常见（40至49岁，3,530例[24.35%]；50至59岁，3,991例[27.53%]）。青少年患者中淋巴瘤的比例较高（54.46%）。NET的比例随年龄增长而下降，癌的比例随年龄增长而上升。癌、肉瘤和淋巴瘤在男性中更为常见，黑色素瘤在女性中更为常见。最常见的部位是直肠（11,066例[76.34%]）。淋巴瘤在近端结肠中更常见。黑色素瘤、胃肠道间质瘤和NET大多发生在直肠。共有10,155例患者（70.06%）被分类为局限性疾病。
本研究具有重要意义，因为它是第一项研究结直肠非腺癌发病率的研究。确定了基于人口统计学因素的不同病变发病率差异。本研究将在癌症预防和诊断项目中发挥作用。
