DiSario J A, Burt R W, Kendrick M L, McWhorter W P
Division of Gastroenterology, University of Utah Health Sciences Center, Salt Lake City.
Dis Colon Rectum. 1994 Dec;37(12):1277-80. doi: 10.1007/BF02257796.
To examine clinical characteristics of colorectal cancers of rare histologic types compared with adenocarcinomas.
Review of a population-based registry with complete ascertainment.
There were 7,422 colorectal cancers, 4,900 (66 percent) colonic and 2,522 (34 percent) rectal. Two hundred fifty-five cancers (3 percent) were of nonadenocarcinoma varieties including 75 (33 percent) squamous, 74 (33 percent) malignant carcinoids, 37 (16 percent) transitional cell-like, 25 (11 percent) lymphomas, 9 (4 percent) sarcomas, and 2 (0.9 percent) melanomas. Sixty (1.2 percent) of the colon cancers occurred in the appendix, and proportionately more carcinoids accounted for these tumors. Compared with adenocarcinomas, colonic and rectal carcinoids and colonic lymphomas accounted for a larger proportion of cancers in the younger age groups. The elderly had proportionately fewer colonic carcinoids. Colonic carcinoids, rectal squamous-cell cancers, and rectal transitional cell-like cancers were more common in women. Colonic lymphomas had a worse prognosis than adenocarcinomas. Survival was better with colonic and rectal carcinoids and rectal transitional cell-like cancers than with adenocarcinomas.
Colorectal cancers of histologic varieties other than adenocarcinoma have distinctive epidemiologic and clinical traits.
研究罕见组织学类型的结直肠癌与腺癌相比的临床特征。
回顾一个基于人群且确定信息完整的登记系统。
共有7422例结直肠癌，其中4900例（66%）为结肠癌，2522例（34%）为直肠癌。255例癌症（3%）为非腺癌类型，包括75例（33%）鳞状细胞癌、74例（33%）恶性类癌、37例（16%）移行细胞样癌、25例（11%）淋巴瘤、9例（4%）肉瘤和2例（0.9%）黑色素瘤。60例（1.2%）结肠癌发生在阑尾，这些肿瘤中类癌所占比例更高。与腺癌相比，结肠和直肠类癌以及结肠淋巴瘤在较年轻年龄组的癌症中所占比例更大。老年人结肠类癌的比例相对较少。结肠类癌、直肠鳞状细胞癌和直肠移行细胞样癌在女性中更为常见。结肠淋巴瘤的预后比腺癌差。结肠和直肠类癌以及直肠移行细胞样癌的生存率比腺癌好。
除腺癌外，其他组织学类型的结直肠癌具有独特的流行病学和临床特征。
