Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Social Determinants of Health Research Center, Midwifery Department, Tabriz University of Medical Sciences, Tabriz, Iran.
Clin Nutr ESPEN. 2021 Feb;41:104-109. doi: 10.1016/j.clnesp.2020.11.001. Epub 2020 Nov 26.
The exact mechanism of Parkinson's disease (PD) is not fully understood yet, but it is suggested that inflammation is one of its contributing factors. Among several inflammatory factors, adipokines, especially leptin may have a great role in this mechanism; since it is not only causing inflammation, but it can also play other roles in the body that may contribute to the symptoms described for PD. Regarding the contradictions in the association of serum leptin levels with Parkinson's disease, a systematic review and meta-analysis was performed to have a more accurate estimation of this relationship.
Published literature was obtained by searching PubMed, Embase, Cochrane Library, Scopus, Ovid, ProQuest and Google Scholar. Random-effect model analysis was used to calculate pooled standard mean difference (SMD) with 95% confidence interval (CI). Heterogeneity was tested with the heterogeneity statistic Q and quantified using I. Newcastle-Ottawa scale was used to assess the study quality.
Six studies including a total number of 198 PD patients and 182 controls were finally included in the meta-analysis. Serum leptin levels in PD patients were non-significantly lower than those in control group (SMD = -0.40 ng/ml, 95% CI -2.33-1.53). Subgroup analyses revealed that serum leptin levels of PD patients and controls in either females or males didn't show any significant difference.
This meta-analysis revealed that leptin level doesn't show any significant difference between PD patients and healthy controls, even when taking the participants' gender into consideration.
帕金森病（PD）的确切发病机制尚未完全阐明，但炎症被认为是其发病因素之一。在几种炎症因子中，脂肪因子，尤其是瘦素，在这一机制中可能具有重要作用；因为它不仅会引起炎症，而且在体内还可能发挥其他作用，从而导致 PD 患者出现的症状。鉴于血清瘦素水平与帕金森病之间的关联存在矛盾，我们进行了系统评价和荟萃分析，以便更准确地评估这种关系。
通过检索 PubMed、Embase、Cochrane 图书馆、Scopus、Ovid、ProQuest 和 Google Scholar 获得已发表的文献。使用随机效应模型分析计算合并标准均数差（SMD）及其 95%置信区间（CI）。使用异质性统计量 Q 检验异质性，并使用 I 量化异质性。使用纽卡斯尔-渥太华量表评估研究质量。
最终纳入了 6 项研究，共包括 198 例 PD 患者和 182 例对照组。PD 患者的血清瘦素水平显著低于对照组（SMD=-0.40ng/ml，95%CI-2.33-1.53）。亚组分析显示，PD 患者和对照组中女性或男性的血清瘦素水平均无显著差异。
本荟萃分析显示，PD 患者与健康对照组的血清瘦素水平无显著差异，甚至考虑到参与者的性别因素也是如此。
