白藜芦醇对肥胖有什么影响？系统评价和荟萃分析。

What is the effect of resveratrol on obesity? A systematic review and meta-analysis.

机构信息

Department of Nursing in Public Health, Federal University of Pelotas, Rio Grande do Sul, Brazil.

Faculty of Nursing, Federal University of Pelotas, Brazil.

出版信息

Clin Nutr ESPEN. 2021 Feb;41:59-67. doi: 10.1016/j.clnesp.2020.11.025. Epub 2020 Dec 18.

DOI:10.1016/j.clnesp.2020.11.025

PMID:33487308

Abstract

BACKGROUND & AIMS: Obesity is increasing worldwide. Resveratrol appears as a substance capable of helping with weight loss. This study aimed to investigate the resveratrol effect in the treatment of obesity in general population.

METHODS

An online search was conducted in the following databases: Pubmed, LILACS, Scielo, Scopus and Web of Science. Experimental studies that investigated the effects between resveratrol supplementation for weight loss treatment, as well as its relationship with overweight and obesity were included. Observational and non-human studies were excluded. The Cochrane scale was used to assess the quality of the studies.

RESULTS

Nineteen studies were included, of which only three demonstrated some type of positive effect. In the meta-analysis, there was no significant effect on weight loss [SMD: 0.03; CI95%: -0,44, 0,49; p = 0,01; I2 = 82%], and body mass index (BMI) [SMD: 0.01; CI95%: -0,39, 0,41; p = 0,01; I2 = 72%]. A small effect was found on the waist circumference [SMD: -1.04; CI95%: -1,86, -0,27; p = 0,01; I2 = 87%].

CONCLUSION

This systematic review with meta-analysis demonstrated that supplementation with resveratrol does not have an anti-obesity effect.

摘要

背景与目的

肥胖在全球范围内不断增加。白藜芦醇似乎是一种有助于减肥的物质。本研究旨在调查白藜芦醇在治疗普通人群肥胖中的作用。

方法

在以下数据库中进行了在线搜索：Pubmed、LILACS、Scielo、Scopus 和 Web of Science。纳入了研究白藜芦醇补充剂对减肥治疗效果以及与超重和肥胖关系的实验研究。排除了观察性和非人类研究。使用 Cochrane 量表评估研究质量。

结果

共纳入 19 项研究，其中只有 3 项显示出某种类型的积极效果。荟萃分析显示，白藜芦醇补充剂对体重减轻没有显著影响[SMD：0.03；95%CI：-0.44，0.49；p=0.01；I2=82%]，对体重指数（BMI）也没有显著影响[SMD：0.01；95%CI：-0.39，0.41；p=0.01；I2=72%]。但发现腰围有较小的影响[SMD：-1.04；95%CI：-1.86，-0.27；p=0.01；I2=87%]。