Ayadi Sirine, Hammami Bouthaina, Boudaouara Ons, Boudawara Tahya, Kallel Souha, Charfeddine Ilhem
Service d'oto-rhino-laryngologie, CHU d'Habib-Bourguiba, Sfax, Tunisie.
Service d'oto-rhino-laryngologie, CHU Habib-Bourguiba, Sfax, Tunisie.
Ann Pathol. 2021 Jun;41(3):326-329. doi: 10.1016/j.annpat.2020.08.005. Epub 2021 Jan 22.
We report a rare case of thyrolipoma-thyrolipomatosis' association. A 48-year-old patient, with a past history of high blood pressure and chronic renal failure secondary to AA amyloidosis, presented with a midline neck swelling increasing in size since one year. Ultrasound showed a multinodular goiter, the worst nodule was left-lobar and categorized as EU-TIRADS 4. Grossly, cut section of the thyroïd specimen showed a yellow-tan left-lobar nodule measuring 2.5cm, the surrounding tissue had a diffuse yellow-brown appearance with scattered whitish areas. Histopathologic examination revealed that the nodule corresponded to a follicular adenoma.Thyroid fat infiltration was noticed both within the nodule and in the neighboring parenchyma. Thus, the diagnosis of an association thyrolipoma-thyrolipomatosis was rendered. The association of thyrolipoma-thyrolipomatosis is a very rare occurrence of unclear pathogenesis. To the best of our knowledge, this report describes the second case in the literature. The diagnosis is retained on the basis of certain histological features, revealing mature adipose tissue within thyroid gland as a combined nodular and diffuse pattern.
我们报告了一例罕见的甲状腺脂肪瘤-甲状腺脂肪过多症关联病例。一名48岁患者,有高血压病史及继发于AA淀粉样变性的慢性肾衰竭病史,自一年前起出现颈部中线肿胀且逐渐增大。超声显示为多结节性甲状腺肿,最严重的结节位于左叶,分类为EU-TIRADS 4类。大体上,甲状腺标本切面显示一个2.5厘米的黄褐色左叶结节,周围组织呈弥漫性黄棕色外观,有散在的白色区域。组织病理学检查显示该结节为滤泡性腺瘤。在结节内及邻近实质均发现甲状腺脂肪浸润。因此,诊断为甲状腺脂肪瘤-甲状腺脂肪过多症关联。甲状腺脂肪瘤-甲状腺脂肪过多症的关联极为罕见,发病机制不明。据我们所知,本报告描述的是文献中的第二例病例。该诊断基于某些组织学特征得以确立,这些特征显示甲状腺内成熟脂肪组织呈结节状和弥漫性混合模式。