Zemheri Ebru, Karadag Ayşe Serap, Yılmaz İsmail
Department of Pathology, Sağlık Bilimleri University, Umraniye Training Hospital, Istanbul, Turkey.
Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Goztepe Training Hospital, Istanbul, Turkey.
Indian J Dermatol. 2020 Nov-Dec;65(6):526-529. doi: 10.4103/ijd.IJD_585_18.
Superficial CD34-positive fibroblastic tumor (SCPFT), a newly described neoplasm is a rare mesenchymal neoplasm of intermediate malignancy. A 63-year-old man presented with a painless, slow-growing, skin-colored nodule of 8 × 4 mm in diameter on the right side of the neck. It was completely resected. Histologically, a tumor located in the subcutis with the minimally infiltrative pattern was detected. The tumor was composed of variably enlarged bizarre and pleomorphic spindle to polygonal cells. Tumor cells were stained strongly diffuse positive with CD34 and weak positive with keratin, negative with STAT6, FLI-1, ERG, S100, desmin, and smooth muscle actin. The fluorescence hybridization (FISH) analysis was negative for gene rearrangement. As per the findings, the case was diagnosed as a SCPFT. It is a borderline mesenchymal neoplasm occurring within the superficial soft tissues with distinctive morphological and immunohistochemical features.
浅表性CD34阳性成纤维细胞瘤（SCPFT）是一种新描述的肿瘤，是一种罕见的具有中等恶性程度的间叶性肿瘤。一名63岁男性患者右侧颈部出现一个直径8×4mm的无痛、生长缓慢、肤色结节。该结节被完整切除。组织学检查发现，肿瘤位于皮下，呈微浸润模式。肿瘤由大小不一、怪异且多形性的梭形至多边形细胞组成。肿瘤细胞CD34染色呈强弥漫阳性，角蛋白染色呈弱阳性，STAT6、FLI-1、ERG、S100、结蛋白和平滑肌肌动蛋白染色均为阴性。荧光原位杂交（FISH）分析基因重排为阴性。根据这些发现，该病例被诊断为SCPFT。它是一种发生于浅表软组织的交界性间叶性肿瘤，具有独特的形态学和免疫组化特征。
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