Yim Jung Eun, Kwon Hyeong Mok, Kim Hye Ri, Shin Dong Hoon, Choi Jong Soo, Choi Joon Hyuk, Bae Young Kyung
Department of Dermatology, Yeungnam University College of Medicine, Daegu, Korea.
Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
Ann Dermatol. 2023 May;35(Suppl 1):S25-S29. doi: 10.5021/ad.20.328.
Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described disease entity characterized by marked nuclear pleomorphism, low mitotic count, and diffuse CD34 positivity. It is a rare, distinctive, low-grade fibroblastic neoplasm. To date, only 44 cases have been reported in the English-language literature. Herein, we report two cases of SCPFT involving a 48-year-old male and a 22-year-old male with superficial tumors on the right and left thighs, respectively. Excision was performed in both cases. Histologically, both tumors showed spindle-to-epithelioid cells arranged in fascicular or sheet-like patterns. Most cells displayed granular or eosinophilic glassy cytoplasm, marked nuclear pleomorphism, and a low mitotic rate. On immunohistochemical staining, tumor cells were diffusely positive for CD34 and negative for S100 protein, smooth muscle actin, and desmin. After wide excision, neither patient experienced recurrence or metastasis after 16 months and 11 months of clinical follow-up, respectively. To the best of our knowledge, these are the first two cases of SCPFT reported in Korea. We believe these case reports would contribute to the clinicopathological understanding of SCPFT and assist clinicians in differentiating this tumor from other superficial soft tissue neoplasms.
浅表性CD34阳性成纤维细胞瘤(SCPFT)是一种最近描述的疾病实体,其特征为明显的核多形性、低有丝分裂计数和弥漫性CD34阳性。它是一种罕见的、独特的、低级别成纤维细胞肿瘤。迄今为止,英文文献中仅报道了44例。在此,我们报告两例SCPFT,分别涉及一名48岁男性和一名22岁男性,肿瘤分别位于右大腿和左大腿浅表部位。两例均行手术切除。组织学上,两个肿瘤均显示梭形至上皮样细胞呈束状或片状排列。大多数细胞表现为颗粒状或嗜酸性玻璃样细胞质、明显的核多形性和低有丝分裂率。免疫组织化学染色显示,肿瘤细胞CD34弥漫性阳性,S100蛋白、平滑肌肌动蛋白和结蛋白阴性。广泛切除后,两名患者分别经过16个月和11个月的临床随访,均未出现复发或转移。据我们所知,这是韩国首次报道的两例SCPFT。我们相信这些病例报告将有助于对SCPFT的临床病理理解,并协助临床医生将该肿瘤与其他浅表软组织肿瘤相鉴别。