The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People's Republic of China.
Department of Medical Biology, College of Basic Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People's Republic of China.
Int J Nanomedicine. 2021 Jan 12;16:297-314. doi: 10.2147/IJN.S284357. eCollection 2021.
The glucose-sensitive self-adjusting drug delivery system simulates the physiological model of the human pancreas-secreting insulin and then precisely regulates the release of hypoglycemic drugs and controls the blood sugar. Thus, it has good application prospects in the treatment of diabetes. Presently, there are three glucose-sensitive drug systems: phenylboronic acid (PBA) and its derivatives, concanavalin A (Con A), and glucose oxidase (GOD). Among these, the glucose-sensitive polymer carrier based on PBA has the advantages of better stability, long-term storage, and reversible glucose response, and the loading of insulin in it can achieve the controlled release of drugs in the human environment. Therefore, it has become a research hotspot in recent years and has been developed very rapidly. In order to further carry out a follow-up study, we focused on the development process, performance, and application of PBA and its derivatives-based glucose-sensitive polymer drug carriers, and the prospects for the development of this field.
葡萄糖敏感型自调式药物输送系统模拟了人体胰腺分泌胰岛素的生理模型，然后精确调节降血糖药物的释放，并控制血糖。因此，它在糖尿病治疗方面具有良好的应用前景。目前，有三种葡萄糖敏感药物系统：苯硼酸（PBA）及其衍生物、伴刀豆球蛋白 A（Con A）和葡萄糖氧化酶（GOD）。其中，基于 PBA 的葡萄糖敏感聚合物载体具有更好的稳定性、长期储存和可逆的葡萄糖响应性，并且其中装载的胰岛素可以实现药物在人体环境中的控制释放。因此，它已成为近年来的研究热点，并得到了快速发展。为了进一步进行后续研究，我们重点研究了基于 PBA 及其衍生物的葡萄糖敏感聚合物药物载体的开发过程、性能和应用，以及该领域的发展前景。
