Department of Orthopedics, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do 200-702, Korea.
Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, China.
Molecules. 2019 Mar 19;24(6):1089. doi: 10.3390/molecules24061089.
Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked three-dimensional (3D) structure endows the glucose-sensitive gels with great physicochemical properties. The PBA-based platforms with cross-linked structures have found promising applications in self-regulated drug delivery systems. This article summarizes some recent attempts at the developments of PBA-mediated glucose-sensitive gels for self-regulated drug delivery. The PBA-based glucose-sensitive gels, including hydrogels, microgels, and nanogels, are expected to significantly promote the development of smart self-regulated drug delivery systems for diabetes therapy.
葡萄糖敏感型药物平台在自我调节药物输送领域极具吸引力。基于硼酸（BA）的药物载体，特别是苯硼酸（PBA），已被设计用于葡萄糖敏感的自我调节胰岛素输送。近年来，PBA 功能化凝胶引起了更多的关注。交联的三维（3D）结构赋予葡萄糖敏感凝胶优异的物理化学性质。基于 PBA 的具有交联结构的平台在自我调节药物输送系统中找到了有前途的应用。本文总结了一些最近在开发用于自我调节药物输送的 PBA 介导的葡萄糖敏感凝胶方面的尝试。基于 PBA 的葡萄糖敏感凝胶，包括水凝胶、微凝胶和纳米凝胶，有望极大地促进用于糖尿病治疗的智能自我调节药物输送系统的发展。
