Mohammadi Akbar, Moghaddas Jafarsadegh
Transport Phenomena Research Center, Faculty of Chemical Engineering, Sahand University of Technology, Tabriz Iran.
Turk J Chem. 2020 Jun 1;44(3):614-633. doi: 10.3906/kim-1912-18. eCollection 2020.
The aim of this work was to prepare biodegradable starch aerogels as drug carriers. The effective parameters in the synthesis and the optimal values of these parameters were determined using Minitab experimental design software. Ibuprofen was selected as a model drug for the dissolution study and loaded into optimized aerogel during the last solvent exchange step. The Fourier Transform Infrared Spectroscopy (FTIR) analysis showed that ibuprofen has been successfully loaded into the aerogel matrix without any effect on the aerogel nature. The drug loading was calculated to be 29%. The isotherm of ibuprofen adsorption into aerogels matrices followed from the Freundlich isotherm. The in vitro release tests of crystalline ibuprofen and ibuprofen-loaded potato starch aerogel were investigated with simulated gastric and intestinal fluids in USP 2 apparatus. It was shown that the dissolution rate of ibuprofen could be dramatically changed. Also, an improvement in the dissolution rate of ibuprofen was achieved by performing the dissolution test first in the gastric medium for 120 min and then in the intestinal medium for up to 270 min. A higher release rate (100%) was observed at the end of the in vitro experiment.
这项工作的目的是制备可生物降解的淀粉气凝胶作为药物载体。使用Minitab实验设计软件确定了合成过程中的有效参数及其最佳值。选择布洛芬作为溶出度研究的模型药物，并在最后的溶剂交换步骤中将其负载到优化的气凝胶中。傅里叶变换红外光谱（FTIR）分析表明，布洛芬已成功负载到气凝胶基质中，且对气凝胶性质没有任何影响。计算得出药物负载量为29%。布洛芬在气凝胶基质中的吸附等温线符合Freundlich等温线。采用USP 2装置，用模拟胃液和肠液对结晶布洛芬和负载布洛芬的马铃薯淀粉气凝胶进行了体外释放试验。结果表明，布洛芬的溶出速率可能会发生显著变化。此外，通过先在胃介质中进行120分钟的溶出试验，然后在肠介质中进行长达270分钟的溶出试验，布洛芬的溶出速率得到了提高。在体外实验结束时观察到较高的释放率（100%）。
