McCune W J, MacGuire A, Aisen A, Gebarski S
Department of Medicine, University of Michigan Hospitals, Ann Arbor 48109-0358.
Arthritis Rheum. 1988 Feb;31(2):159-66. doi: 10.1002/art.1780310202.
Cranial magnetic resonance imaging in 28 systemic lupus erythematosus patients who had experienced 30 acute neuropsychiatric events showed focal brain lesions in 16 of 30 events (53%) and low brain volume (atrophy) in 20 of 30 events (67%). Definite focal lesions were significantly more frequent in patients with clinically localized neurologic deficits (8 of 8, 100%), or seizures (5 of 6, 83%) than in patients without such localizing signs (3 of 16, 19%). Many of these lesions were occult on intravenous contrast-enhanced x-ray computed tomography. In 2 patients, lesions in gray matter resolved within 2 or 3 weeks, in association with clinical improvement. Magnetic resonance imaging is an important technique for detecting the extent of brain injury in cerebral lupus.
对28例系统性红斑狼疮患者进行的头颅磁共振成像检查显示，在30次急性神经精神事件中，16次（53%）出现局灶性脑损伤，20次（67%）出现脑容量降低（萎缩）。明确的局灶性病变在有临床定位神经功能缺损的患者（8例中的8例，100%）或癫痫患者（6例中的5例，83%）中比无此类定位体征的患者（16例中的3例，19%）更常见。这些病变中的许多在静脉注射对比剂增强的X线计算机断层扫描中是隐匿的。在2例患者中，灰质病变在2至3周内消退，同时临床症状改善。磁共振成像对于检测狼疮性脑病的脑损伤程度是一项重要技术。
