Jacobs L, Kinkel P R, Costello P B, Alukal M K, Kinkel W R, Green F A
Dent Neurologic Institute, Millard Fillmore Hospital, Buffalo, NY 14209.
J Rheumatol. 1988 Apr;15(4):601-6.
Magnetic resonance imaging was sued to examine the brains of 13 patients with systemic lupus erythematosus (SLE) who had experienced symptoms and signs of encephalopathy. All the patients had normal computerized tomographic scans. Four patients with abnormal magnetic resonance imaging studies had active central nervous system disease. None of the 9 patients with normal scans had active nervous system involvement at the time of study. Parenchymal lesions were usually located in the region of the corticomedullary junction or in the deep periventricular white matter. In coronal sections, some of the corticomedullary lesions extended centripetally as thin irregular lines into the white matter approximating the course of penetrating arterioles of the brain. The parenchymal lesions resolved in 4 months in 1 patient, but persisted unchanged in the others despite clinical improvement or a stable clinical course. It is likely that the parenchymal lesions of these patients represent intrinsic vasculopathy of small cerebral vessels and perivascular microinfarctions associated with SLE.
采用磁共振成像对13例患有系统性红斑狼疮（SLE）且出现脑病症状和体征的患者的脑部进行检查。所有患者的计算机断层扫描结果均正常。4例磁共振成像研究异常的患者患有活动性中枢神经系统疾病。9例扫描结果正常的患者在研究时均无神经系统受累。实质病变通常位于皮质髓质交界处或脑室周围深部白质区域。在冠状切面中，一些皮质髓质病变呈细不规则线向心性延伸至白质，近似脑穿通小动脉的走行。1例患者的实质病变在4个月内消退，但其他患者的病变尽管临床症状改善或病情稳定，仍持续不变。这些患者的实质病变可能代表与SLE相关的小脑小血管的原发性血管病变和血管周围微梗死。
