Marmara University, Department of Chemical Engineering, 34722, Istanbul, Turkey.
Marmara University, Department of Chemical Engineering, 34722, Istanbul, Turkey.
Carbohydr Polym. 2019 Oct 15;222:115007. doi: 10.1016/j.carbpol.2019.115007. Epub 2019 Jun 19.
Polymeric films with enhanced mechanical performance were fabricated by incorporation of bone ash (BA) at various concentrations (0-25 v. %) into chitosan/gelatin (CTS/GEL) polymeric structure as a wound healing-dressing. The test results for mechanical performance of polymeric films proved that the encapsulation of BA into the polymeric films enhances the elastic modulus and tensile strength of polymeric films significantly. Oxygen permeability and water vapor transmission rate (WVTR) of films were also improved by BA reinforcement. Ciprofloxacin was chosen as the antibacterial model drug. The release of ciprofloxacin was provided in a more controlled manner at pH 7.4 owing to the incorporation of bone ash into the polymeric films. Also, drug loaded films showed great antibacterial activity against Escherichia coli and Bacillus subtilis bacteria. The results prove that ciprofloxacin loaded BA reinforced CTS/GEL composite films are potentially applicable in controlled drug delivery as wound dressings.
采用骨粉（BA）以不同浓度（0-25 v. %）掺入壳聚糖/明胶（CTS/GEL）聚合物结构中，制备出具有增强机械性能的聚合物膜，作为伤口愈合敷料。聚合物膜力学性能测试结果表明，BA 的包封显著提高了聚合物膜的弹性模量和拉伸强度。BA 增强也提高了薄膜的氧气透过率和水蒸气透过率（WVTR）。环丙沙星被选为抗菌模型药物。由于骨粉的掺入，聚合物膜在 pH 值为 7.4 时的释放更具可控性。此外，载药薄膜对大肠杆菌和枯草芽孢杆菌具有很强的抗菌活性。结果表明，载有环丙沙星的 BA 增强 CTS/GEL 复合膜有望作为控释药物的伤口敷料。
