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新冠康复的漫长历程:免疫恢复与免疫支持

The Long Haul of COVID-19 Recovery: Immune Rejuvenation versus Immune Support.

作者信息

Bland Jeffrey S

出版信息

Integr Med (Encinitas). 2020 Dec;19(6):18-22.

Abstract

With the COVID-19 pandemic still affecting communities all over the world and "Long Haul" chronic health issues emerging, it is time for us to look back at past multi-symptom health conditions that required a different approach to their treatment, beyond just managing symptoms. It is important for us to consider how to apply what we have learned about immune rejuvenation and its impact on conditions associated with chronic immune dysfunction. We know more than we ever have before about how to reduce chronic inflammation at its source through the support of selective immune cell autophagy/mitophagy and improved immune cell mitochondrial activity, followed by remodeling of the immune epigenome, and-ultimately-a reset of immune function.

摘要

随着新冠疫情仍在影响世界各地的社区,以及“长期”慢性健康问题的出现,现在是我们回顾过去那些需要采用不同治疗方法的多症状健康状况的时候了,而不仅仅是控制症状。对我们来说,重要的是要考虑如何应用我们所学到的关于免疫恢复及其对与慢性免疫功能障碍相关疾病的影响的知识。我们比以往任何时候都更清楚如何通过支持选择性免疫细胞自噬/线粒体自噬和改善免疫细胞线粒体活性,从源头上减少慢性炎症,随后重塑免疫表观基因组,并最终重置免疫功能。

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本文引用的文献

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Autophagy-Sirt3 axis decelerates hematopoietic aging.自噬-Sirt3 轴延缓造血衰老。
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