Sheng LiQin, Ma HaiRong, Shi YuanYuan, Dai ZhenYu, Zhong JianGuo, Chen Fei, Pan PingLei
Department of Neurology, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, China.
Department of Central Laboratory, School of Medicine, Affiliated Yancheng Hospital, Southeast University, Yancheng, China.
Front Neurosci. 2021 Jan 6;14:600423. doi: 10.3389/fnins.2020.600423. eCollection 2020.
Cortical thickness (CTh) via surface-based morphometry analysis is a popular method to characterize brain morphometry. Many studies have been performed to investigate CTh abnormalities in migraine. However, the results from these studies were not consistent and even conflicting. These divergent results hinder us to obtain a clear picture of brain morphometry regarding CTh alterations in migraine. Coordinate-based meta-analysis (CBMA) is a promising technique to quantitatively pool individual neuroimaging studies to identify consistent brain areas involved. Electronic databases (PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, WanFang, and SinoMed) and other sources (bioRxiv and reference lists of relevant articles and reviews) were systematically searched for studies that compared regional CTh differences between patients with migraine and healthy controls (HCs) up to May 15, 2020. A CBMA was performed using the Seed-based d Mapping with Permutation of Subject Images approach. In total, we identified 16 studies with 17 datasets reported that were eligible for the CBMA. The 17 datasets included 872 patients with migraine (average sample size 51.3, mean age 39.6 years, 721 females) and 949 HCs (average sample size 59.3, mean age 44.2 years, 680 females). The CBMA detected no statistically significant consistency of CTh alterations in patients with migraine relative to HCs. Sensitivity analysis and subgroup analysis verified this result to be robust. Metaregression analyses revealed that this CBMA result was not confounded by age, gender, aura, attack frequency per month, and illness duration. Our CBMA adds to the evidence of the replication crisis in neuroimaging research that is increasingly recognized. Many potential confounders, such as underpowered sample size, heterogeneous patient selection criteria, and differences in imaging collection and methodology, may contribute to the inconsistencies of CTh alterations in migraine, which merit attention before planning future research on this topic.
通过基于表面的形态测量分析得出的皮质厚度（CTh）是一种用于描述脑形态测量的常用方法。许多研究已开展以调查偏头痛患者的CTh异常情况。然而，这些研究的结果并不一致，甚至相互矛盾。这些不同的结果阻碍我们清晰了解偏头痛患者CTh改变的脑形态测量情况。基于坐标的元分析（CBMA）是一种很有前景的技术，可定量汇总个体神经影像学研究，以识别一致的受累脑区。我们系统检索了电子数据库（PubMed、EMBASE、Web of Science、中国知网、万方和中国生物医学文献数据库）以及其他来源（bioRxiv以及相关文章和综述的参考文献列表），以查找截至2020年5月15日比较偏头痛患者与健康对照（HCs）之间区域CTh差异的研究。使用基于种子点的d映射和受试者图像置换方法进行了CBMA。我们总共确定了16项研究，报告了17个数据集符合CBMA的要求。这17个数据集包括872例偏头痛患者（平均样本量51.3，平均年龄39.6岁，721例女性）和949例HCs（平均样本量59.3，平均年龄44.2岁，680例女性）。CBMA未检测到偏头痛患者相对于HCs的CTh改变具有统计学意义的一致性。敏感性分析和亚组分析证实该结果具有稳健性。元回归分析表明，该CBMA结果不受年龄、性别、先兆、每月发作频率和病程的影响。我们的CBMA增加了神经影像学研究中日益受到认可的重复危机的证据。许多潜在的混杂因素，如样本量不足、患者选择标准的异质性以及成像采集和方法的差异，可能导致偏头痛患者CTh改变的不一致性，在规划该主题的未来研究之前值得关注。
