Yang Zhenzhen, Xu Pengfei, Geng Chaofan, Zhang Hongju
Fuwai Central China Cardiovascular Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Front Neurol. 2022 Jul 26;13:939363. doi: 10.3389/fneur.2022.939363. eCollection 2022.
The study aims to investigate the role of serum albumin (ALB) and creatinine (CRE), bilirubin (BIL), and uric acid (UA) as major intravascular antioxidants in migraine.
We enrolled 148 patients with migraine and 150 age- and sex-matched healthy controls. The serum levels of ALB, TBIL, CRE, and UA were measured in patients with migraine of different subtypes. The risk of migraine was assessed by multiple stepwise logistic regression analysis.
The serum levels of ALB, total BIL (TBIL), CRE, and UA were significantly lower in the migraine group than in the HC group ( < 0.05). The ALB and UA levels were lower during migraine attack periods ( < 0.05). There were no statistically significant differences observed in serum ALB, TBIL, CRE, and UA levels between aura/without aura and episodic/chronic migraine subtypes ( > 0.05). The multiple stepwise logistic regression revealed that ALB [odds ratio (OR) 0.79, 95% confidence interval (CI) 0.69-0.89, < 0.001], TBIL (OR 0.61, 95% CI 0.5-0.75, < 0.001), and UA (OR 0.97, 95% CI 0.96-0.99, = 0.014) were independently associated with migraine. In addition, the serum levels of ALB, TBIL, and UA were significantly lower in the migraine group when compared by sex.
The serum levels of UA, TBIL, ALB, and CRE were lower in the patients with migraine, indicating a lower antioxidant status. In addition, ALB, TBIL, and UA were independently related to migraine. These results could provide insights into the possible role of oxidative stress in the pathogenesis of migraine.
本研究旨在探讨血清白蛋白（ALB）、肌酐（CRE）、胆红素（BIL）和尿酸（UA）作为偏头痛主要血管内抗氧化剂的作用。
我们纳入了148例偏头痛患者和150例年龄及性别匹配的健康对照者。测量不同亚型偏头痛患者的血清ALB、总胆红素（TBIL）、CRE和UA水平。通过多因素逐步逻辑回归分析评估偏头痛风险。
偏头痛组血清ALB、总胆红素（TBIL）、CRE和UA水平显著低于健康对照组（P<0.05）。偏头痛发作期ALB和UA水平较低（P<0.05）。先兆/无先兆与发作性/慢性偏头痛亚型之间血清ALB、TBIL、CRE和UA水平无统计学显著差异（P>0.05）。多因素逐步逻辑回归显示，ALB[比值比（OR）0.79，95%置信区间（CI）0.69-0.89，P<0.001]、TBIL（OR 0.61，95%CI 0.5-0.75，P<0.001）和UA（OR 0.97，95%CI 0.
