Herman G, Raimondi B
Maternal-Fetal Medicine, Monmouth Medical Center, Philadelphia, Pennsylvania.
Am J Perinatol. 1988 Apr;5(2):168-71. doi: 10.1055/s-2007-999679.
Currently, gestational diabetes is often defined by the criteria of O'Sullivan, with those patients not included as gestationally diabetic being considered normal. Recently, Tallarigo and coworkers reported that serum glucose variations within the normal range could affect the birthweight of the neonate and also could relate to the frequency of complications often associated with diabetes in pregnancy. This study confirms the correlation between the plasma glucose concentration at 2 hours on the 100 gm, 3-hour glucose tolerance test and birthweight. When women demonstrating 2-hour glucose values of 139 mg/dl or less are compared with those demonstrating values 140 mg/dl or greater, fetuses from the group with higher plasma glucose values had higher birthweights (+211 gm) and were more often macrosomic (24.4 versus 8.6%). We were unable to identify any relationship between these small variations of glucose tolerance and pregnancy complications, such as delivery by cesarean section, birth trauma, pregnancy-induced hypertension, or congenital anomalies.
目前，妊娠期糖尿病通常依据奥沙利文标准来定义，那些未被纳入妊娠期糖尿病范畴的患者被视为正常。近期，塔拉里戈及其同事报告称，正常范围内的血糖变化会影响新生儿出生体重，且可能与妊娠糖尿病常见并发症的发生频率相关。本研究证实了100克3小时葡萄糖耐量试验中2小时血浆葡萄糖浓度与出生体重之间的相关性。将2小时血糖值为139毫克/分升或更低的女性与血糖值为140毫克/分升或更高的女性进行比较时，血浆葡萄糖值较高组的胎儿出生体重更高（重211克），且巨大儿的发生率更高（分别为24.4%和8.6%）。我们未能发现这些糖耐量的微小变化与妊娠并发症之间存在任何关联，如剖宫产、产伤、妊娠高血压或先天性畸形。
