乳腺导管原位癌的临床病理特征：617例中国患者的分析
Clinicopathological Characteristics of Breast Ductal Carcinoma In Situ: An Analysis of Chinese Population of 617 Patients.
作者信息
Mao Guangmin, Shi Xiu-Hua, Wang Xiaofang, Zhang Xiaomeng, Chen Xingxing, Ma Jinli, Yu Xiaoli, Zhang Zhen, Guo Xiaomao
机构信息
Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
J Oncol. 2021 Jan 5;2021:8854418. doi: 10.1155/2021/8854418. eCollection 2021.
BACKGROUND
The purpose of this study was to describe the clinicopathological characteristics of breast DCIS in Chinese women and compare with that of patients in western countries.
METHOD
From December 2005 to December 2015, 617 women diagnosed with pure DCIS after surgery at our institution were enrolled, and the clinicopathological characteristics were described.
RESULTS
In this study, the percentage of patients detected on screening, diagnosed at ≤50 years of age, with tumor size ≤2.0 cm, and with low-intermediate grade was 39.4%, 56.7%, 72.6%, and 77.4%, respectively, as compared to 50-80%, 20-30%, 70-90%, and 40-60% in published reports from western countries. The percentage of ER-positive patients was 76.3% in this study, which is similar to the mean expression rate of ER (mean: 68.7%, range: 49-96.6%) reported previously.
CONCLUSIONS
The clinicopathological characteristics of Chinese DCIS patients include less detection on screening, younger age at diagnosis, and more low-intermediate nuclear grade.
背景
本研究旨在描述中国女性乳腺导管原位癌（DCIS）的临床病理特征，并与西方国家患者的特征进行比较。
方法
2005年12月至2015年12月，纳入在我院接受手术后诊断为单纯DCIS的617名女性，并描述其临床病理特征。
结果
在本研究中，筛查发现的患者、诊断时年龄≤50岁、肿瘤大小≤2.0 cm以及低-中级别的患者百分比分别为39.4%、56.7%、72.6%和77.4%，而西方国家已发表报告中的相应比例分别为50-80%、20-30%、70-90%和40-60%。本研究中雌激素受体（ER）阳性患者的百分比为76.3%，与先前报道的ER平均表达率（平均：68.7%，范围：49-96.6%）相似。
结论
中国DCIS患者的临床病理特征包括筛查发现率较低、诊断时年龄较轻以及低-中级核分级较多。
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