Asimeng Bernard Owusu, Nyankson Emmanuel, Efavi Johnson Kwame, Nii Amarkai Amartey, Manu Gloria Pokuaa, Tiburu Elvis
University of Ghana, School of Engineering Sciences, Department of Biomedical Engineering, P.O. Box LG 74, Accra, Ghana.
University of Ghana, School of Engineering Sciences, Department of Materials Science & Engineering, P.O. Box LG 74, Accra, Ghana.
Int J Biomater. 2020 Dec 10;2020:2630735. doi: 10.1155/2020/2630735. eCollection 2020.
Magnetic FeO nanoparticles were synthesized from maize leaves and plantain peels extract mediators. Particles were characterized, and the inhibitory effects were studied on HeLa cells in vitro using cyclic voltammetry (CV). Voltammograms from the CV show that FeO NPs interaction with HeLa cells affected their electrochemical behavior. The nanoparticles formed with higher Fe/Fe molar ratio (2.8 : 1) resulted in smaller crystallite sizes compared to those formed with lower Fe/Fe molar ratio (1.4 : 1). The particles with the smallest crystallite size showed higher anodic peak currents, whereas the larger crystallite sizes resulted in lower anodic peak currents. The peak currents relate to cell inhibition and are confirmed by the half-maximum inhibitory concentration (IC). The findings show that the particles have a different inhibitory mechanism on HeLa cells ion transfer and are promising to be further exploited for cancer treatment.
磁性FeO纳米颗粒是由玉米叶和车前草果皮提取物介质合成的。对颗粒进行了表征，并使用循环伏安法（CV）在体外研究了其对HeLa细胞的抑制作用。CV的伏安图表明，FeO纳米颗粒与HeLa细胞的相互作用影响了它们的电化学行为。与较低Fe/Fe摩尔比（1.4 : 1）形成的纳米颗粒相比，较高Fe/Fe摩尔比（2.8 : 1）形成的纳米颗粒具有更小的微晶尺寸。微晶尺寸最小的颗粒显示出更高的阳极峰值电流，而较大的微晶尺寸则导致较低的阳极峰值电流。峰值电流与细胞抑制有关，并通过半数最大抑制浓度（IC）得到证实。研究结果表明，这些颗粒对HeLa细胞离子转移具有不同的抑制机制，有望进一步用于癌症治疗。
