Kipritci Zehra, Gurol Yesim, Celik Gulden
Yeditepe University Hospital, İstanbul, Turkey.
Acıbadem University School of Medicine, Department of Clinical Microbiology, Istanbul, Turkey.
Int J Microbiol. 2020 Nov 4;2020:8853298. doi: 10.1155/2020/8853298. eCollection 2020.
is a bacterial pathogen in the human stomach which infects about 50% of the world population. Untreated infection can lead to various diseases leading to cancer. Some of the strains are asymptomatic, but some of them cause more severe diseases. Standard treatment protocol used for the treatment of infection is triple therapy, which includes omeprazole as a proton pump inhibitor (PPI) and two antibiotics usually consist of amoxicillin and clarithromycin or metronidazole. In the recent years, because of the increase in the rate of antibiotic resistance, the eradication rate has decreased.
We evaluated 140 patients who applied to a university hospital gastroenterology department and underwent biopsy during endoscopy. In these patients, we analysed floroquinolone and clarithromycin resistance using the GenoType® HelicoDR (Hain Life Science, Germany). We also used the real-time method for clarithromycin resistance.
We found the number and rate of floroquinolone resistance as 20 (25.6%) and clarithromycine resistance as 31 (39.7%). With the real-time PCR method, we detected clarithromycine resistance in 26 (33.3%) patients. These results were not statistically significant. . Our results show similarity to the other studies held in our country. There should be more studies for the policy of eradication through our country.
是一种存在于人类胃部的细菌病原体，全球约50%的人口受其感染。未经治疗的感染可导致各种疾病甚至引发癌症。部分菌株无症状，但有些会导致更严重的疾病。用于治疗感染的标准治疗方案是三联疗法，其中包括作为质子泵抑制剂（PPI）的奥美拉唑以及两种抗生素，通常为阿莫西林和克拉霉素或甲硝唑。近年来，由于抗生素耐药率上升，根除率有所下降。
我们评估了140名到大学医院胃肠病科就诊并在内镜检查时接受活检的患者。在这些患者中，我们使用GenoType® HelicoDR（德国海因生命科学公司）分析了氟喹诺酮和克拉霉素耐药性。我们还采用实时方法检测克拉霉素耐药性。
我们发现氟喹诺酮耐药的数量和比率分别为20（25.6%），克拉霉素耐药的数量和比率分别为31（39.7%）。采用实时聚合酶链反应方法，我们在26名（33.3%）患者中检测到克拉霉素耐药。这些结果无统计学意义。我们的结果与我国开展的其他研究相似。我国应开展更多关于根除策略的研究。
