Gu Cheng, Peng Wenpan, Wang Zhichao, Xu Yong, Han Di, Zhou Xianmei
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Department of Respiratory Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
Evid Based Complement Alternat Med. 2020 Dec 31;2020:9485746. doi: 10.1155/2020/9485746. eCollection 2020.
Cough variant asthma (CVA) is a unique type of asthma characterized by cough as the only or primary clinical presentation. Inhaled glucocorticoid is the main treatment in clinical practice currently, but its efficacy remains relatively unsatisfactory. Traditional Chinese medicine has certain advantages in the treatment of CVA, and at present, the most commonly used traditional Chinese medicine is Suhuang Zhike Capsule (SZC). The aim of this study was to systematically evaluate the efficacy and safety of SZC in the treatment of CVA using a meta-analysis. A comprehensive search of papers published in the PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature database (CBM), Wanfang Database, and VIP Information (VIP) from January 2018 to June 2019 was conducted. Review Manager 5.3 was used to carry out a meta-analysis of 10 studies that fulfilled the inclusion criteria. In a total of 10 randomized controlled trials, 896 CVA patients were included. The results showed the following: (1) compared with conventional Western medicine, SZC can effectively increase the efficacy rate of CVA (RR 1.25, 95% CI, 1.16-1.35, < 0.00001) and (2) compared with other traditional Chinese medicines, SZC can effectively increase the efficacy rate of CVA (RR 1.44, 95% CI, 1.01-2.05, =0.05), In conclusion, our study builds on existing clinical evidence showing that SZC is safe and effective in treating CVA. However, larger randomized controlled trials are required for further validation.
咳嗽变异性哮喘（CVA）是一种独特的哮喘类型，其特征是以咳嗽作为唯一或主要临床表现。吸入性糖皮质激素是目前临床实践中的主要治疗方法，但其疗效仍相对不尽人意。中医在CVA的治疗中具有一定优势，目前最常用的中药是苏黄止咳胶囊（SZC）。本研究的目的是通过荟萃分析系统评价SZC治疗CVA的疗效和安全性。对2018年1月至2019年6月发表在PubMed、Embase、Cochrane图书馆、中国知网（CNKI）、中国生物医学文献数据库（CBM）、万方数据库和维普资讯（VIP）上的论文进行了全面检索。使用Review Manager 5.3对符合纳入标准的10项研究进行荟萃分析。在总共10项随机对照试验中，纳入了896例CVA患者。结果如下：（1）与传统西药相比，SZC可有效提高CVA的有效率（RR 1.25，95%CI，1.16 - 1.35，<0.00001）；（2）与其他中药相比，SZC可有效提高CVA的有效率（RR 1.44，95%CI，1.01 - 2.05，=0.05）。总之，我们的研究基于现有临床证据表明，SZC治疗CVA安全有效。然而，需要更大规模的随机对照试验进行进一步验证。
