Xiong Jian, Qi WenChuan, Yang Han, Zou SiTing, Kong Jing, Wang ChengLong, Zhou YuanFang, Liang FanRong
Chengdu University of Traditional Chinese Medicine, Chengdu 6100752, Sichuan, China.
Guangxi University of Traditional Chinese Medicine, Nanning 5300013, Guangxi, China.
Evid Based Complement Alternat Med. 2021 Apr 2;2021:6694936. doi: 10.1155/2021/6694936. eCollection 2021.
In recent years, there have been many clinical reports on acupuncture treatment of cough-variant asthma, but no researcher has objectively analysed and evaluated the efficacy and safety of acupuncture treatment of cough-variant asthma from the perspective of evidence-based medicine.
To systematically evaluate the clinical efficacy and safety of acupuncture in treating cough-variant asthma and to provide reference values for clinical decision-making.
The comprehensive computer retrieval Chinese journal full-text database (CNKI), Chinese science and technology periodical database (VIP), ten thousand data knowledge service platform (WanFang Data), PubMed, Embase, and the Cochrane Library were used to collect literature for relevant randomized controlled trials (RCT) of acupuncture treatment of cough-variant asthma, as well as to retrieve papers and add reference retrieval after literature review, in accordance with the standard of literature filtering, data extraction, and quality evaluation. The data were meta-analysed using ReviewManager5.3 software recommended by Cochrane.
A total of 11 randomized controlled clinical studies were screened and included, comprising 929 patients. The results of the meta-analysis showed that, compared with the control group, acupuncture intervention on CVA could enhance the total clinical effectiveness rate, reduce the relapse rate of drug withdrawal, relieve symptoms of cough, phlegm, and diaphragmatic congestion, and improve lung function-related indicators and immune inflammation indicators. There were statistically significant differences in all efficacy evaluation criteria.
The clinical curative effect of acupuncture treatment for cough-variant asthma is precise and has certain advantages in relieving symptoms and reducing the recurrence rate. However, the low quality of the evaluation in the RCT research literature is a problem, and more high-quality clinical randomized controlled trials are needed to further verify the comprehensive clinical efficacy and safety of this treatment. Registration number: PROSPERO (no. CRD42020155244) (https://www.crd.york.ac.uk/prospero/).
近年来，关于针刺治疗咳嗽变异性哮喘的临床报道众多，但尚无研究者从循证医学角度对针刺治疗咳嗽变异性哮喘的疗效及安全性进行客观分析与评价。
系统评价针刺治疗咳嗽变异性哮喘的临床疗效及安全性，为临床决策提供参考依据。
通过计算机全面检索中国期刊全文数据库（CNKI）、中国科技期刊数据库（VIP）、万方数据知识服务平台、PubMed、Embase及Cochrane图书馆，收集针刺治疗咳嗽变异性哮喘的相关随机对照试验（RCT）文献，并在文献回顾后进行论文检索及补充参考文献检索，按照文献筛选、数据提取及质量评价标准进行。采用Cochrane推荐的ReviewManager5.3软件对数据进行Meta分析。
共筛选并纳入11项随机对照临床研究，涉及929例患者。Meta分析结果显示，与对照组相比，针刺干预咳嗽变异性哮喘可提高临床总有效率，降低撤药复发率，缓解咳嗽、咳痰及胸闷症状，改善肺功能相关指标及免疫炎症指标。各项疗效评价指标差异均有统计学意义。
针刺治疗咳嗽变异性哮喘临床疗效确切，在缓解症状及降低复发率方面具有一定优势。然而，RCT研究文献评价质量较低是一个问题，需要更多高质量的临床随机对照试验进一步验证该疗法的综合临床疗效及安全性。注册号：PROSPERO（编号CRD42020155244）（https://www.crd.york.ac.uk/prospero/）。
