硬皮马勃菌素全合成的进展

Progress in the total synthesis of inthomycins.

作者信息

Senapati Bidyut Kumar

机构信息

Department of Chemistry, Prabhat Kumar College, Contai, 721404, India, Tel.: +91 8145207480.

出版信息

Beilstein J Org Chem. 2021 Jan 7;17:58-82. doi: 10.3762/bjoc.17.7. eCollection 2021.

DOI:10.3762/bjoc.17.7

PMID:33488832

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7801802/

Abstract

The inthomycin family of antibiotics, isolated from strains, are interesting molecules for synthesis due to their characteristic common oxazole polyene chiral allylic β-hydroxycarbonyl fragments and significant biological activities. The full structural motif of the inthomycins is found in several more complex natural products including the oxazolomycins, 16-methyloxazolomycin, curromycins A and B, and KSM-2690. This review summarises the application of various efforts towards the synthesis of inthomycins and their analogues systematically.

摘要

从菌株中分离得到的因托霉素类抗生素，由于其具有特征性的常见恶唑多烯手性烯丙基β-羟基羰基片段和显著的生物活性，是合成方面令人感兴趣的分子。在包括恶唑霉素、16-甲基恶唑霉素、库罗霉素A和B以及KSM-2690在内的几种更复杂的天然产物中发现了因托霉素的完整结构基序。本综述系统地总结了在因托霉素及其类似物合成方面所做的各种努力的应用情况。