短、无锡合成三种茵芋碱。
Short, Tin-Free Synthesis of All Three Inthomycins.
机构信息
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Chemistry. 2018 Nov 13;24(63):16753-16756. doi: 10.1002/chem.201803794. Epub 2018 Oct 19.
Abstract
The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross-couplings and an enantioselective Kiyooka aldol reaction.
摘要
茵丝菌素是一类结构和生物多样性丰富的天然产物，从链霉菌属的物种中分离得到。本文报道了一种模块化合成路线的实施情况，该路线能够实现所有三种茵丝菌素的对映选择性合成。关键步骤包括 Suzuki 和 Sonogashira 交叉偶联反应以及对映选择性 Kiyooka 羟醛缩合反应。
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