Thompson E N, Dallimore N S, Brook D L
Department of Child Health, University of Wales College of Medicine, Llandough Hospital, Penarth, S. Glam., UK.
Br J Cancer. 1988 Jan;57(1):127-9. doi: 10.1038/bjc.1988.25.
A study of parental cancer in 326 children referred to a single Paediatric Oncology Unit found a significant increase in breast cancer in mothers of children with solid tumours. The 5 tumours found were 8.9 times the expected number. This increase could not be accounted for by any of the known risk factors for breast cancer. The incidence of cancer in mothers of leukaemic children and in all groups of fathers was not significantly raised. Further prospective studies in the mothers of young children with soft tissue tumours are needed to clarify the groups at risk and to determine whether counselling and surveillance of these mothers is appropriate.
一项针对转诊至单一儿科肿瘤科室的326名儿童的父母患癌情况的研究发现，实体瘤患儿的母亲患乳腺癌的几率显著增加。所发现的5例肿瘤是预期数量的8.9倍。这种增加无法用任何已知的乳腺癌风险因素来解释。白血病患儿的母亲以及所有组别的父亲患癌的发生率并未显著升高。需要对患有软组织肿瘤的幼儿的母亲进行进一步的前瞻性研究，以明确高危人群，并确定对这些母亲进行咨询和监测是否合适。
