Gulinac Milena, Dikov Dorian, Lichev Simeon, Velikova Tsvetelina
Department of General and Clinical Pathology, Medical University of Plovdiv Bulgaria.
Grand Hospital de l'Este Francilien Jossigny, France.
Am J Clin Exp Immunol. 2020 Dec 15;9(5):64-72. eCollection 2020.
Bladder carcinoma (BC) is one of the most common malignancies of the urinary system in developed countries, with a high number of recurrences. The secondary lymphoid organs (SLO) are crucial for initiating the adaptive immune response. They are developed as a part of a genetically preprogrammed process during embryogenesis. However, SLO's organogenesis can be reduplicated de novo in other tissues by a process termed lymphoid neo-genesis, giving rise to tertiary lymphoid structures (TLS). These well-organized lymphoid structures in cancer are essential modulators of cancer immunologic response, and the histological examination of TLS gave a new strategy for cancer immunotherapy. This review explores the biological and histological characteristics of TLS in muscle non-invasive and invasive BC.
膀胱癌（BC）是发达国家泌尿系统最常见的恶性肿瘤之一，复发率很高。次级淋巴器官（SLO）对于启动适应性免疫反应至关重要。它们是在胚胎发育过程中作为基因预编程过程的一部分发育而成的。然而，SLO的器官发生可以通过一种称为淋巴新生的过程在其他组织中重新从头复制，从而产生三级淋巴结构（TLS）。癌症中这些组织良好的淋巴结构是癌症免疫反应的重要调节因子，TLS的组织学检查为癌症免疫治疗提供了新策略。本综述探讨了肌肉非侵袭性和侵袭性BC中TLS的生物学和组织学特征。
