伴有多处胸膜转移的肝细胞癌出现远隔效应完全消退。
Abscopal complete regression of hepatocellular carcinoma with multiple pleural metastases.
作者信息
Ohmatsu Kenta, Hashimoto Yaichiro, Kawanishi Miki, Ishii Yuka, Kono Sawa, Kuribayashi Shigehiko, Ariizumi Shunichi, Karasawa Kumiko
机构信息
Department of Radiation Oncology, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 Japan.
Department of Gastroenterology, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 Japan.
出版信息
Int Cancer Conf J. 2020 Sep 25;10(1):54-58. doi: 10.1007/s13691-020-00446-y. eCollection 2021 Jan.
Hepatocellular carcinoma (HCC) with extrahepatic metastasis is rare, and its prognosis is extremely poor. There is no standard treatment for HCC with extrahepatic metastasis. We report a case of abscopal effect in HCC with multiple pleural metastases in a patient who was treated with focal radiotherapy to extrahepatic metastasis, and achieved long-term survival. We performed radiotherapy only to the tumor in inferior vena cava and the proximal pleural tumor. The regimen comprised a total dose of 30 Gy administered in ten fractions to these tumors, followed by 12 Gy administered in four fractions (a total of 42 Gy in 14 fractions) as boost irradiation to the remaining tumor, and a complete regression was achieved. There have been some case reports on abscopal effects in HCC, but no reports on patients with multiple pleural metastases. To our knowledge, this is the first case report on the abscopal effect of focal radiotherapy resulting in complete regression of distant multiple pleural metastases.
伴有肝外转移的肝细胞癌（HCC）较为罕见，其预后极差。对于伴有肝外转移的HCC尚无标准治疗方法。我们报告了1例伴有多处胸膜转移的HCC出现远隔效应的病例，该患者接受了针对肝外转移灶的局部放疗，并实现了长期生存。我们仅对下腔静脉肿瘤及近端胸膜肿瘤进行了放疗。放疗方案为对这些肿瘤分10次给予总剂量30 Gy，随后分4次给予12 Gy（14次共42 Gy）作为对残留肿瘤的追加照射，最终实现了完全缓解。已有一些关于HCC远隔效应的病例报告，但尚无关于伴有多处胸膜转移患者的报告。据我们所知，这是首例关于局部放疗远隔效应导致远处多处胸膜转移完全缓解的病例报告。
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