Archer C B, Whittaker S, Greaves M W
St John's Hospital for Diseases of the Skin, Leicester Square, London, U.K.
Br J Dermatol. 1988 Feb;118(2):255-60. doi: 10.1111/j.1365-2133.1988.tb01783.x.
In two patients with painful cutaneous leiomyomata, induction of pain by the application of an ice cube allowed assessment of a number of topical and systemic treatments aimed at reducing or preventing the pain. In one patient the alpha-adrenoceptor blocker, phenoxybenzamine alleviated cold-induced pain. In the second patient, topical 9% hyoscine hydrobromide (an anticholinergic agent) decreased pain induced by the ice cube, but was not helpful in reducing lesional pain due to cold weather.
在两名患有疼痛性皮肤平滑肌瘤的患者中，通过冰敷诱发疼痛，从而能够评估多种旨在减轻或预防疼痛的局部和全身治疗方法。在一名患者中，α-肾上腺素能受体阻滞剂酚苄明可减轻冷诱导的疼痛。在另一名患者中，局部使用9%氢溴酸东莨菪碱（一种抗胆碱能药物）可减轻冰敷诱发的疼痛，但对减轻因寒冷天气导致的皮损疼痛并无帮助。
