Menzies Health Institute Queensland, Griffith University, Southport, QLD, Australia.
Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Nathan, QLD, Australia.
Front Cell Infect Microbiol. 2021 Jan 8;10:607779. doi: 10.3389/fcimb.2020.607779. eCollection 2020.
can infect the brain and has been linked to late-onset dementia. , which infects mice, is often used to model human chlamydial infections. While it has been suggested to be also important for modelling brain infection, nervous system infection by has not been reported in the literature. has been shown to infect the olfactory bulb in mice after intranasal inoculation, and has therefore been suggested to invade the brain the olfactory nerve; however, nerve infection has not been shown to date. Another path by which certain bacteria can reach the brain is the trigeminal nerve, but it remains unknown whether species can infect this nerve. Other bacteria that can invade the brain the olfactory and/or trigeminal nerve can do so rapidly, however, whether spp. can reach the brain earlier than one-week post inoculation remains unknown. In the current study, we showed that can within 48 h invade the brain the olfactory nerve, in addition to infecting the trigeminal nerve. We also cultured the glial cells of the olfactory and trigeminal nerves and showed that readily infected the cells, constituting a possible cellular mechanism explaining how the bacteria can invade the nerves without being eliminated by glial immune functions. Further, we demonstrated that olfactory and trigeminal glia differed in their responses to , with olfactory glia showing less infection and stronger immune response than trigeminal glia.
能够感染大脑，并与迟发性痴呆有关。感染老鼠的，通常用于模拟人类衣原体感染。虽然有人认为它对模拟大脑感染也很重要，但文献中尚未报道过由引起的神经系统感染。已经表明，在鼻腔接种后，会感染小鼠的嗅球，因此有人认为它会通过嗅神经侵入大脑；然而，迄今为止尚未证明有神经感染。某些细菌进入大脑的另一种途径是通过三叉神经，但尚不清楚是否可以感染该神经。其他可以侵入大脑的细菌通过嗅神经和/或三叉神经，但尚不清楚是否可以比接种后一周更快地到达大脑。在本研究中，我们表明可以在 48 小时内通过嗅神经侵入大脑，除了感染三叉神经之外。我们还培养了嗅神经和三叉神经的神经胶质细胞，并表明能够轻易感染这些细胞，这构成了一种可能的细胞机制，解释了细菌如何在不被神经胶质免疫功能消除的情况下侵入神经。此外，我们证明了嗅神经和三叉神经的神经胶质细胞对的反应不同，嗅神经胶质细胞的感染程度较低，免疫反应较强。
