健康志愿者对局部应用2%卡替洛尔和0.5%噻吗洛尔的眼部及心血管反应。
Ocular and cardiovascular response to topical carteolol 2% and timolol 0.5% in healthy volunteers.
作者信息
Brazier D J, Smith S E
机构信息
Department of Clinical Pharmacology, St Thomas's Hospital Medical School (UMDS), London.
出版信息
Br J Ophthalmol. 1988 Feb;72(2):101-3. doi: 10.1136/bjo.72.2.101.
Abstract
Ocular and cardiovascular effects of carteolol 2%, timolol 0.5%, and dummy eyedrops have been measured in a single dose double-blind crossover study in six healthy volunteers. Both drugs lowered intraocular pressure and reduced exercise-induced tachycardia. Neither produced a significant change in resting heart rate or blood pressure. The two agents appear comparable as regards ocular hypotensive and cardiovascular effects.
摘要
在一项针对六名健康志愿者的单剂量双盲交叉研究中，对2%的卡替洛尔、0.5%的噻吗洛尔以及安慰剂眼药水的眼部和心血管效应进行了测量。两种药物均降低了眼压，并减轻了运动诱发的心动过速。两者均未使静息心率或血压发生显著变化。就眼部降压和心血管效应而言，这两种药物似乎相当。
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