局部用噻吗洛尔与血清脂蛋白
Topical timolol and serum lipoproteins.
作者信息
West J, Longstaff S
机构信息
Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield.
出版信息
Br J Ophthalmol. 1990 Nov;74(11):663-4. doi: 10.1136/bjo.74.11.663.
Abstract
Oral timolol taken for the treatment of systemic hypertension has been shown to affect adversely serum lipoprotein levels. In a 15-week study on 19 patients topical timolol therapy for raised intraocular pressure was found to have no significant adverse effect on serum lipoprotein levels. This is reassuring in view of the large number of patients on this form of long term therapy, and selection of the type of beta blocker to use should not be influenced by lipid changes associated with the oral form of the drug.
摘要
用于治疗全身性高血压的口服噻吗洛尔已被证明会对血清脂蛋白水平产生不利影响。在一项针对19名患者的为期15周的研究中，发现局部使用噻吗洛尔治疗眼压升高对血清脂蛋白水平没有显著不良影响。鉴于大量患者采用这种长期治疗方式，这一点令人放心，并且在选择使用的β受体阻滞剂类型时，不应受与该药物口服形式相关的脂质变化影响。
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本文引用的文献
1
Dynamics and kinetics of ophthalmic timolol.
Clin Pharmacol Ther. 1980 Apr;27(4):471-7. doi: 10.1038/clpt.1980.66.
2
Effects of diuretic and beta-blocker therapy in the Medical Research Council Trial.医学研究委员会试验中利尿剂和β受体阻滞剂疗法的效果。
Am J Med. 1984 Feb 27;76(2A):45-51. doi: 10.1016/0002-9343(84)90956-2.
3
Plasma timolol in glaucoma patients.青光眼患者的血浆噻吗洛尔
Ophthalmology. 1984 Nov;91(11):1361-3. doi: 10.1016/s0161-6420(84)34141-0.
4
The triglyceride issue: a view from Framingham.甘油三酯问题：来自弗雷明汉的观点。
Am Heart J. 1986 Aug;112(2):432-7. doi: 10.1016/0002-8703(86)90296-6.
5
Ocular and cardiovascular response to topical carteolol 2% and timolol 0.5% in healthy volunteers.健康志愿者对局部应用2%卡替洛尔和0.5%噻吗洛尔的眼部及心血管反应。
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J Hypertens. 1985 Aug;3(4):297-306. doi: 10.1097/00004872-198508000-00001.
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Acta Med Scand. 1988;223(4):321-6. doi: 10.1111/j.0954-6820.1988.tb15880.x.
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