通过软性隐形眼镜进行药物递送。
Drug delivery through soft contact lenses.
作者信息
Jain M R
机构信息
Department of Ophthalmology, New Teaching Medical College Hospital, Jodhpur, India.
出版信息
Br J Ophthalmol. 1988 Feb;72(2):150-4. doi: 10.1136/bjo.72.2.150.
Abstract
Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both modes of treatment provided therapeutically effective levels against most of the common ocular pathogens for varying intervals of 2 to 12 hours.
摘要
对466例等待老年性白内障手术且结膜下及通过新索氟隆70和新索氟隆85镜片接受氯霉素、庆大霉素或羧苄青霉素治疗的患者进行了临床研究。在不同时间间隔对房水药物水平进行了生物学评估。软性隐形眼镜提供的药物渗透率明显高于结膜下治疗。两种治疗方式在2至12小时的不同时间段内对大多数常见眼部病原体均提供了治疗有效的水平。
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